FGFR1和IGF1R在肺鳞癌中的表达及其临床意义

目的 探讨成纤维生长因子受体1（FGFR1）、胰岛素样生长因子受体1（IGF1R）在肺鳞癌组织中的表达及两者的临床意义。方法 采用免疫组化法检测260例肺鳞癌术后患者的癌组织及40例癌旁正常组织中FGFR1、IGF1R的表达，分析两者表达与临床病理特征及预后的关系。采用Kaplan-Meier法进行生存分析，用Cox回归模型分析影响肺鳞癌预后的独立因素。结果 FGFR1、IGF1R在肺鳞癌组织中的阳性表达率分别为51.92％（135／260）、55.4％（144／260），均明显高于癌旁正常组织的32.5％（13／40）、30.0％（12／40），差异均有统计学意义（P＜0.05）。FGFR1在肺鳞癌组织中的表达与吸烟、淋巴结转移有关，IGF1R表达仅与淋巴结转移有关（P＜0.005）。FGFR1、IGF1R蛋白阳性表达者的中位OS分别为38.21个月、38.48个月，均低于阴性表达者的42.55个月、42.51个月（P＞0.05）。Cox多因素分析显示，FGFR1、IGF1R表达及淋巴结转移为肺鳞癌患者术后的独立预后因子。结论 FGFR1、IGF1R均参与了肺鳞癌的发生、发展，并且二者均为肺鳞癌的不良预后指标，并有望成为分子靶向治疗的新靶点。

Expression of FGFR1, IGF1R in resected squamous cell lung cancer and their clinical significance

Objective To investigate the expression of fibroblast growth factor receptor 1（ FGFR1）,insulin-like growth factor（ IGF1R） in resected squamous cell lung cancer tissue and their clinical significance. Methods The immunohistochemical method was applied to detect the protein expression of FGFR1,IGF1 R on tissue sections from 260 squamous cell lung cancer and 40 adjacent normal tissues. Then the relationship between expression of FGFR1,IGF1 R and clinicopathological characteristics and prognosis. The overall survival（ OS） was estimated using the Kaplan-Meier method. The factors affecting the prognosis of squamous cell lung cancer were analyzed by Cox multivariate survival analysis. Results The positive expression rates of FGFR1,IGF1 R in squamous cell lung cancer tisssues was 32. 5%（ 13 /40） and 30. 0%（ 12 /40）,higher than 32. 5%（ 13 /40） and 30. 0%（ 12 /40） of adjacent normal tissues with significant differences（ P 〈 0. 05）. FGFR1 expression was related with smoking and lymph node metastasis,and the IGF1 R expression was only related with lymph node metastasis（ P 〈 0. 05）. The median OS of patients with FGFR1 and IGF1 R positive expression was 38. 21,38. 48 months,lower than 42. 55,42. 51 months of patients with FGFR1 and IGF1 R negtive expression（ P 〈 0. 05）.Multivariate survival analysis showed that FGFR1,IGF1 R expression and lymph node metastasis may act as independent prognostic factors for squamous cell lung cancer. Conclusion Expression of FGFR1 and IGF1 R may be involved in the occurrence and development of b squamous cell lung cancer. They may serve as markers for predicting the prognosis of patients with squamous cell lung cancer.