妊娠糖尿病患者超敏C反应蛋白与胰岛素抵抗相关性的初步探讨

目的:探讨妊娠糖尿病(GDM)患者血清超敏C反应蛋白(hs-CRP)与胰岛素抵抗(IR)的关系。方法:选择41例妊娠糖尿病孕妇(GDM组)、40例糖耐量正常(NGT)的孕妇作对照(NC组),用ELISA方法测定hs-CRP水平,同时计算稳态模式胰岛素抵抗指数(HOMA-IR)。结果:①GDM组的hs-CRP、HOMA-IR分别为(10.80±3.57)mg/L、(3.96±2.16)mg/L,NC组分别为(5.96±2.56)mg/L、(2.59±0.71)mg/L,两组比较差异有统计学意义(P<0.01);②多元线性逐步回归分析显示,HOMA-IR是影响hs-CRP最为显著的因素。结论:GDM患者的血清hs-CRP水平明显升高与IR密切相关,hs-CRP与GDM的发病有关。

Investigation on correlation between serum hypersensitivity C-reactive protein and insulin resistance in patients with gestational diabetes mellitus

Objective:To explore the correlation between serum hypersensitivity C-reactive protein (hs-CRP) and insulin resistance (IR) in patients with gestational diabetes mellitus (GDM).Methods:The levels of hs-CRP from 41 patients with GDM (GDM group) and 40 pregnant women with normal glucose tolerance (NC group) were detected by ELISA. Homeostasis model insulin resistance index (HOMA-IR) was applied to assess the status of IR.Results:①The levels of hs-CRP and HOMA-IR were (10.80±3.57) mg/L,(3.96±2.16) in GDM group and (5.96±2.56) mg/L,(2.59±0.71) in NC group,there was significant difference in the levels of hs-CRP and HOMA-IR between two groups (P<0.01 );②A multiple linear stepwise regression analysis indicated that HOMA-IR was the most important effect factors of hs-CRP.Conclusion:The level of hs-CRP increase in women with GDM,which is related to IR and may participate in the pathogenesis of GDM.