不良妊娠结局危险因素的Meta分析

目的:利用Meta分析方法探讨影响我国妇女不良妊娠结局的危险因素,为制定预防措施提供依据。方法:通过文献检索收集不良妊娠结局病例对照研究的相关文献,应用严格的纳入和剔除标准进行筛检,采用随机效应模型和固定效应模型通过Review Manager4.2软件进行分析评价。结果:纳入文献21篇,累计病例3298例,对照27886例。解脲脲原体感染合并OR值为5.57(1.66,18.63);沙眼衣原体感染合并OR值为4.15(1.95,8.87);多胎妊娠合并OR值为6.42(2.06,19.99);妊娠期高血压疾病合并OR值2.87(1.68,4.91):胎位异常合并OR值为3.46(2.71,4.42);流产史合并OR值为1.15(0.91,91.45)。结论:本研究分析显示不良妊娠结局的危险因素由强到弱依次为:多胎妊娠,解脲脲原体感染,沙眼衣原体感染,胎位异常和妊娠期高血压疾病。

Meta-analysis on risk factors of adverse pregnancy outcome

Objective:To explore the risk factors of adverse pregnancy outcome by meta-analysis,provide evidences for prevention.Methods:Case-control studies for meta-analysis were collected by literature retrieval according to strict inclusion and exclusion criteria.Fixed effect model and random,effect model were applied to the analysis.The analysis was performed on Review Manager 4.2 software.Results:21 published papers were adopted.The cumulative cases and control cases were 3 298 and 27 886,respectively.The merged OR values and 95% CI of the infections of UU,CT,polyembryony,hypertensive disorder complicating pregnancy,malposition and the history of abortion were 5.57(1.66,18.63),4.15(1.95,8.87),6.42(2.06,19.99),2.87(1.68,4.91),3.46(2.71,4.42) and 1.15(0.91,91.45).Conclusion:The main risk factors of adverse pregnancy outcome are polyembryony,infection of UU and CT,malposition and hypertensive disorder complicating pregnancy.