早发型和晚发型情感性障碍的遗传效应比较

为了解早发型和晚发型情感性障碍间是否存在遗传效应的差异，对同时符合中国精神疾病分类方案与诊断标准第２版和美国精神障碍诊断和统计手册第４版情感性障碍诊断标准的１８０例患者，以３０岁为界，划分为早发组（１１３例）和晚发组（６７例）。所得资料行单因素分析，用多基因阈值理论进行遗传率的估算。结果显示，早发组有精神疾病家族史多，一级亲属中情感性障碍的发病风险率高，一级亲属的加权平均遗传率高，脑部ＣＴ显示有器质性改变者少，与晚发组比较，差异均有显著性。提示二者存在着遗传异质性。

A comparison of genetic effect between the early and late onset affective disorders

The purpose of the study was to explore the possible difference of genetic effect between the early onset and late onset affective disorders. 180 subjects who met both the 2nd edition of the Chinese Classification and diagnostic Criteria of Mental Disorders and the 4th edition of Diagnostic and Statistical Manual of mental disorders for affective disorder were divided into the early onset and late onset subgroups (113 cases and 67 cases) according to cut off point of age 30 years. The data were examined with the single factor analysis and the heritability was estimated with multiple gene threshold theory. Our results showed that the patients in the early onset group had more family history of mental disorders. More risk suffering from affective disorder and higher weighted mean heritability were found in the first degree relatives of the patients in early onset group compared with those in late onset subgroup. The brain pathological changes with CT scan in the early onset group were less than that in the late onset group. The results suggest that there is a genetic heterogenity in early onset and late onset affective disorders.