硝苯毗啶及山莨菪碱对大鼠血小板膜流动性及血小板聚集功能的影响

硝苯吡啶与山莨菪碱分别可使大鼠血小板膜微粘度最大增加38.3％及37.1％.并使大鼠血小板5min最大聚集率降低40.5％及42.0％(P值皆小于0.001)。药物效应随其浓度增加而增强,当药物浓度达最大药物效应时,再增加浓度反而使其药物效应减弱。两种药物的血小板膜作用曲线及其抑制血小板聚集作用曲线基本相似。

Effects of Nifedipine and Anisodamine on platelet Membrane Fluidity and Platelet Aggregation in Rats

We studied the efficiency of nifedipine on platelet membrane fluidity and platelet aggreagtion compared with that of anisodamine in normal female Wistar rats. Both aentgs appeared in biphasic dose-dependant effects. Increase in the concentration of nifedipine was associated with the increase of its effect on platelet membrane microviscosity (MMV) when its concentration was lower than 100 ng/ml; while increase of its effect on the maximal platelet aggregation in the first five minutes (MAR5) associated with concentration lower than 1000ng/ml. Nifedipine increased MMV by 38.3%(P<0.001) in lOOng/ml and decreased MAR5 by 40.5% (P O.OOl) in 1000 ng/ml. However, when the concentration was higher than these levels, its effect decreased. The efficiency of anisodamine was similiar to that of nifedipine. The maximal effective dose of anisodamine was 5><10 4mol/L, which increased MMV by 37.1% (P<0.00l) and decreased MAR5 by 42.0%(P<0.00l) . The dose-effect relation curves of nifedipine and anisodamine on MMV were in line with those on MAR5.