An assessment of the suitability of bromocresol green for the determination of serum albumin

A comparison of serum albumin levels determined by automated bromocresol green (BCG) methods and a cellulose acetate (CA) method is presented and a considerable discrepancy is shown to exist between the two types of method at low albumin levels. The CA electrophoresis method is shown to give albumin results in good agreement with two immunoprecipitation methods and it is recommended that the BCG method for serum albumin determination should be considered only as a screening method.