| 慢性丙型肝炎患者HCV不同功能区抗体的随访研究 |
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| 引用本文： | 张贺秋,王国华,陈坤,宋晓国,修冰水,凌世淦. 慢性丙型肝炎患者HCV不同功能区抗体的随访研究[J]. 中国输血杂志, 2004, 17(6): 397-399 |
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| 作者姓名： | 张贺秋 王国华 陈坤 宋晓国 修冰水 凌世淦 |
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| 作者单位： | 军事医学科学院基础医学研究所,疫苗工程研究室,北京,100850 |
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| 基金项目： | 国家"十五"重点科技攻关计划资助项目(编号:2001BA705B060) |
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| 摘 要： | 目的 探讨慢性丙型肝炎患者不同功能区抗体的免疫应答。方法 利用基因重组克隆表达丙型肝炎病毒HCV c、NS3、NS4、NS5和HVR1抗原 ,分别包被酶联板 ,以间接ELISA法检测 1991～ 2 0 0 2年采集的 5 8名丙型肝炎患者的 14 4份血清不同功能区抗 HCV。结果 其中 5 0名 (86 .2 0 % )慢性丙型肝炎患者血清 5种相应抗 HCV呈持续阳性。结论 慢性丙型肝炎患者体内HCV c、NS3、NS4、、NS5和HVR1抗体无明显变化 ,未发现这 5种抗体与自愈的关系。
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| 关 键 词： | 丙型肝炎,慢性 不同区 抗-HCV 随访研究 |
| 文章编号： | 1004-549X(2004)06-0397-03 |
| 修稿时间： | 2004-01-19 |
Follow-up study of antibodies against different function regions of hepatitis C virus of chronic hepatitis C patients |
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| ZHANG Heqiu,WANG Guohua,CHEN Kun,et al.. Follow-up study of antibodies against different function regions of hepatitis C virus of chronic hepatitis C patients[J]. Chinese Journal of Blood Transfusion, 2004, 17(6): 397-399 |
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| Authors: | ZHANG Heqiu WANG Guohua CHEN Kun et al. |
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| Affiliation: | ZHANG Heqiu,WANG Guohua,CHEN Kun,et al. Institute of Basic Medical Sciences,Academy of Military Medical Sciences,Bejing 100850,China. |
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| Abstract: | Objective To detect humoral immune response against different function regions of hepatitis C virus (HCV) in chronic hepatitis C patients. Methods Using recombinant dominate epitope antigens, e.g. HCV Core, NS3, NS4, NS5 and chimeric HVR1, a set of ELISA test reagents was formulated. One hundred and forty-four serial sera from 58 chronic hepatitis C patients, collected between 1991 and 2002, were tested for antibodies against HCV different regions by ELISA. Results Eighty (86.20%) patients were persistently positive for antibodies against all 5 functional regions of HCV virus. Conclusions Antibodies against HCV Core, NS3, NS4, NS5 and HVR1 have little change in chronic hepatitis C patients. There is no relationship between the 5 antibodies and self remission of HCV infection. |
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| Keywords: | Chronic HCV patients Anti-HCV different regions Follow-up study |
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