红细胞分布宽度与急性冠状动脉综合征患者近期预后的关系

目的 探讨红细胞分布宽度(RDW)与急性冠状动脉综合征(ACS)患者近期预后的关系.方法 我院2008年1月至2009年4月因ACS住院的患者179例,按RDW＜14.4%和RDW≥14.4%分组,分析2组患者住院期间和出院半年内发生急性心肌梗死(AMI)、恶性心律失常、心力衰竭(HF)、心源性猝死(SCD)等不良事件的情况和入院时的高敏C-反应蛋白(hs-CRP)、脑钠肽(BNP)水平,并探讨RDW与hs-CRp、BNP的关系.结果 RDW≥14.4%组和RDW＜14.4%组住院期间和出院半年内不良心血管事件发生率[AMI分别为39.47%(30/76)、15.53%(16/103),HF分别为22.22%(17/76)、6.80%(7/103),SCD分别为9.21%(7/76)、1.94%(2/103),恶性心律失常分别为11.84%(9/76)、3.90%(4/103),X2值分别为13、126、9.134、0.028、0.042,P均＜0.05]差异有统计学意义,入院时的hs-CRP分别为(9.44±8.03)、(4.64±4.42)mg/L,BNP分别为(357.07±161.60)、(233.17±134.76)ng/L,差异均有统计学意义(t值分别为-2.177、-2.403,P均＜0.05),RDW与hs-CRP、BNP呈正相关(r分别为0.42和0.58,P均＜0.05).结论 RDW与ACS患者的近期预后有关,与hs-CRP、BNP水平正相关.

Study on the relationship between red blood cell distribution width and short term prognosis in patients with acute coronary syndrome

Objective To evaluate the correlations of red blood cell distribution width (RDW) and short term prognosis of patients with acute coronary syndrome.Methods 179 patients with acute coronary syndrome (ACS) treated in our hospital between Jan.2008 to Apr.2009 were grouped by cutoff value of 14.4%.The incidence of acute myocardiac infarct( AMI),malignant arrhythmia,heart falure,sudden cardiac death(SCD) were compared in the two groups when patients were hospitalized and in half years of discharged.High-sensitivity C-reactive protein.(hs-CRP) ,BNP were also compared between the two groups.Results The incidences of cardiac adverse event were different between the two groups(AMI:39.47% vs.15.53% ,HF:22.22% vs.6.80% ,SCD:9.21% vs.1.94% and malignant arrhythmia:11.84% vs.3.90%,P values all less than 0.05 ).hs-CRP were ( 9.44 ± 8.03 ),(4.64 ±4.42) mg/L and BNP were (357.07 ± 161.60),(233.17 ± 134.76) ng/L in the two groups ( P ＜ 0.05 ).RDW is positively correlated with hs-CRP and BNP (r is 0.42 and 0.58 respectively,P-value all less than 0.05).Conclusions The RDW is related to the short term progonosis in patients with ACS,and also positively correllated with plasma hs-CRP and BNP levels.