Abstract: | A study of changes in the ECoG and ECG recorded during combined action ofClostridium perfringens type A toxin and filtrate of a broth culture ofClostridium butyricum showed that desynchronization and subsequent depression of cortical electrical activity developed later than after exposure toCl. perfringens toxin alone. The general character of the changes in the cortical rhythm under these circumstances remained the same as after administration ofCl. perfringens toxin alone. ECG changes arose after shorter intervals. TheCl. butyricum filtrate caused changes in neither the ECoG nor the ECG. It is postulated that the effect of metabolic products ofCl. butyricum is to increase the permeability of the tissue barriers and, consequently, to promote penetration ofCl. perfringens toxin into the tissues, including into the CNS.Departments of Microbiology and Pathological Physiology, N. I. Pirogov Odessa Medical Institute. Laboratory of General Pathology of the Nervous System, Institute of General Pathology and Pathological Physiology, Academy of Medical Sciences of the USSR, Moscow. Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 82, No. 11, pp. 1305–1310, November, 1976. |