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Valproic acid hypersensitivity and desensitization
Authors:Ori Toker  Yuval Tal  Liran Horev  Dorit Shmoeli  Tal Gilboa
Abstract:Rash, a hypersensitivity reaction, is a common cause of withdrawal from an effective antiepileptic drug (AED) in patients with epilepsy. We present a case of successful desensitization to valproic acid in a 12‐year‐old male with childhood absence epilepsy and a hypersensitivity reaction, whose epilepsy did not respond to other AEDs. Desensitization is a practical therapeutic solution for patients who develop a non‐life‐threatening hypersensitivity reaction to an AED for which there may be no substitute.
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