瘦素及细胞因子与妊娠高血压综合征关系实验研究

目的研究瘦素及IL-1、IL-10及TNF-α等细胞因子与妊娠高血压综合征发病进程的相关性。方法采用L-NAME造成大鼠妊娠高血压综合征模型，记录造模前后血压变化，并测定大鼠尿蛋白、血清尿素氮、血清瘦素、IL-1、IL-10及TNF-α浓度。结果妊娠高血压大鼠尿蛋白及血清尿素氮浓度显著升高（P〈0．01），血清瘦素、IL—1及TNF--α水平显著升高（P〈0.01），而IL-10水平显著下降（P〈0．05）。且血清瘦素水平与IL一1及INF-α水平呈正相关。而与IL-10水平呈负相关。结论瘦素及细胞因子水平的变化及相互影响在妊娠高血压综合征疾病发生过程中有重要作用。

The relationship between leptin,cytokines and the pregnancy induced hypertension

Objective To investigate the correlation of levels of leptin,IL-l,IL10 and TNF--α with pregnancy induced hypertension. Methods Hypertension in pregnant rats were induced by injection of L-NAME. Blood pressure was recorded,furthermore the levels of urine protein,serum urea nitrogen,IL-1 ,IL-10 and TNF-α as well as leptin were detected. Results Pregnancy induced hypertension caused a high level of urine protein and serum urea nitrogen （P〈 0.01）. Moreover,the levels of serum leptin,IL-1 and TNF--αconcentrations were increased significantly （P〈0.01）,on the other hand,the level of serum IL-IO concentration reduced significantly （P〈0.05）. In addition,there was a positive correlation between levels of serum leptin and the levels of IL-1 and TNF-α,respectively,while a negative correlation between level of serum leptin and that of IL-10 was observed. Conclusion The changes and the interactions between leptin and cytokines might play an important role in the pathogenesis of pregnancy induced hypertension.