单用替代疗法治疗急性白血病合并DIC的疗效

目的:回顾性观察急性白血病合并弥漫性血管内凝血(DIC)时采用替代疗法加用与不加用肝素的疗效对比。方法:66例急性白血病合并DIC患者均给予替代治疗(输注血浆和血小板),31例(A组)不给予肝素,对照组35例(B组)给予肝素5mg,q8h,不负载。如为急性早幼粒细胞白血病(M3)则同时使用全反式维甲酸或三氧化二砷。结果:DIC在A组和B组的治疗成功率分别为51.6%和54.3%.其差别无显著性,P>0.05。结论:急性自血病合并弥漫性血管内凝血(DIC)时采用替代疗法加用与不加用肝素可能同样有效。

Compare the Effect of Substitutive Therapy with/without Heparin on Acute Leukemia Complicating Disseminated Intravascular Coagulation

Objective:To retrospectively compare the curative effect of substitutive therapy including heparin or not on acute leukemia complicating Disseminated intravascular coagulation(DIC).Method:Total 66 cases were registered in our study,among them 35 cases(Group B) were treated by substitutive therapy including heparin,the other 31 cases(Group A) were treated only by substitutive therapy without heparin.Moreover ATRA or arsenic trioxide was used in those patients with acute promyelocytic leukemia.Result:The cure rates between Group A and Group B were percent 51.6 and percent 54.3 respectively.There was no significant difference between Group A and Group B.Conclusion:Substitutive therapy including heparin or not has the same effect on acute leukemia complying disseminated intravascular coagulation.