150株鲍曼不动杆菌的临床分布及耐药性分析

目的调查鲍曼不动杆菌临床分布特点及耐药性,为临床合理选用抗菌药物提供参考。方法回顾性调查分析临床标本中分离的150株鲍曼不动杆菌的临床感染特点及其耐药性,药敏试验采用琼脂纸片扩散法。结果鲍曼不动杆菌临床分布以ICU及呼吸科最多。临床标本中以呼吸道标本分离率最高,占71.2%,其次为分泌物,占13.5%。鲍曼不动杆菌对美罗培南最敏感,耐药率为5.7%;其次是亚胺培南和头孢哌酮/舒巴坦,耐药率分别为8.9%及17.7%;对其他抗生素均有不同程度的高耐药性、多重耐药性。结论加强对鲍曼不动杆菌的耐药性监测,规范抗菌药物的应用,对保持敏感抗菌药物的抗菌活性具有重要意义。

Clinical Distribution and Drug Resistance Analysis on 150 Strains of Acinetobacter Baumannii

Objective To investigate the clinical distribution and drug resistane of Acinetobacter baumannii in order to provide references for rational use of antibiotics in the clinic. Method The characteristics of infection and drug resistance of 150 strains of Acinetobacter baumannii ,which were isolated from clinic wards,were ana- lyzed retrospectively. The susceptibility was tested by Kirby-Bauer method. Results The most location of Acin- etobacter baumannii were ICU and department of respiratory disease. The isolation rate of respiratory samples were the highest（71.2% ） ,and that of surgical wound were 13.5%. Acinetobacter baumanii had the highest susceptibility to meropenem, the resistant rate was 5.7%, followed by imipenem （8.9%） and cefoperazone- sulbactam（ 17.7% ）. It had higher degree of drug resistance rates to the other antibaeterials,and had higher multidrug-resistantce. Conclusions It is helpful for the maintaining of antibacterial activity of sensitive anti- bactet＇ials to reinforce the monitoring on the drug resistance of Acinetobacter baumanii and to standardize the application of antibacterials.