Implication of the systolic hump in systemic arterial pressure waves |
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Authors: | Dr O Okai A Watanabe |
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Institution: | (1) Department of Clinical Physiology, Kyorin, University School of Health Sciences, Miyashita, 192-8508 Hachioii, Japan;(2) Department of Medical Electronics, Suzuka University of Medical Science, Kishioka, 510-0293 Suzuka, Japan |
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Abstract: | The systolic hump in the aortic blood pressure wave is defined as the aorticresistance component proportional to the aortic
blood flow superimposed on the windkessel component. An electrical analogue comprising a series resistance (aortic resistance)
plus a resistance (peripheral resistance) and capacitance (aortic compliance) in parallel (i.e. windkessel component) is used
for analysis. Curve fitting using the leastsquares method is performed on calculated and measured blood pressure waves from
dogs under haemodynamical conditions induced by infusion of three drugs (noradrenaline, isoproterenol and acetylcholine).
The curve fitting RMS (root mean square) errors are <3% for blood pressure waves and <30% for blood flow waves, with good
agreement between measured and calculated blood flow waveforms. Infusion of noradrenaline and acetylcholine is found to induce
a significant decrease and increase in the aortic resistance, respectively. Although only a small fraction of the blood pressure
wave, the systolic hump has a marked effect on the systolic pressure waveform. |
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Keywords: | Arterial system model Electrical analogue Aortic compliance Pressure and flow waves |
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