| 野黄芪甙元对实验性糖尿病大鼠肾脏的保护作用 |
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| 引用本文： | 吴文清,李英,赵金彩,薛静,李荣芬,于洁,王秀芬,顾连方. 野黄芪甙元对实验性糖尿病大鼠肾脏的保护作用[J]. 中国中西医结合肾病杂志, 2001, 2(8): 444-446 |
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| 作者姓名： | 吴文清 李英 赵金彩 薛静 李荣芬 于洁 王秀芬 顾连方 |
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| 作者单位： | 河北医科大学第三医院肾内科,石家庄,050051 |
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| 摘 要： | 目的P：观察野黄芪甙元对实验性糖尿病大鼠肾脏的保护作用。方法：大鼠随机分为正常对照组，糖尿病组，野黄芪甙元治疗组，腹腔注射链脲佐菌素建立糖尿病动物模型，分别于4，6周测定血糖，Scr,BUN,Ucr，尿蛋白，Ccr，肾重／体重，肾小球平均面积（MGPA），平均体积（MGV），对电镜片进行形态学观察，结果：野黄芪甙元治疗后肾脏肥大指数，尿蛋白较糖尿病组明显减少，肾功能，体视学指标明显改善，结论：中药野黄芪甙元可以改善糖尿病大鼠肾脏功能和结构的损伤，起到保护肾脏的作用。
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| 关 键 词： | 野黄芪甙元 糖尿病肾病 DN 实验药理学 |
| 修稿时间： | 2000-09-18 |
Renal Protective Effect of Erigeron Breviscapus in Diabetic rats |
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| WU Wenqing,LI Ying,ZHAO Jincai,et al. Renal Protective Effect of Erigeron Breviscapus in Diabetic rats[J]. Chinese Journal of Integrated Traditional and Western Nephrology, 2001, 2(8): 444-446 |
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| Authors: | WU Wenqing LI Ying ZHAO Jincai et al |
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| Abstract: | Objective: To observe the renal protective effect of Erigeron brevis capus in diabetic rats.Methods: The rats were randomly divided by following groups:normal control rats,sreptoxotocin diabetic rats and diabetic rats treated with Erigeron breviscapus.The renal function?proteinuria and profile of kidney hy-pertrophy were observed after treatment,The renal tissue were observed by light microscopy and electron mi-croscopy.Results: Kidney hypertrophy index(P<0 05),urinary albumin excretion (P<0 05)in diabetic rats of Erigeron breviscapus ureated group were significantly lower than diabetic rats untreated rats,meanwhile,renal pathologic changes in diabetic rats of Erigeron breviscapus treated group were improved.Conclusion: Erigeron breviscapus has some renal protective effect on diabetic rats. |
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| Keywords: | Erigeron breviscapus Diabetic nephropathy Diabetic rat |
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