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| 多西他赛同步放疗治疗老年晚期非小细胞肺癌 | |
| 引用本文： | 刘海燕,张艳英,宋延梅. 多西他赛同步放疗治疗老年晚期非小细胞肺癌[J]. 实用医药杂志(山东), 2006, 23(7): 786-788 |
| 作者姓名： | 刘海燕 张艳英 宋延梅 |
| 作者单位： | 泰山医学院附属医院肿瘤科,山东泰安271000 |
| 摘 要： | 目的观察多西他赛同步放疗治疗老年晚期非小细胞肺癌(NSCLC)的疗效及毒副反应。方法对病理学或细胞学证实的32例老年晚期非小细胞肺癌患者给予下列治疗:①多西他赛35mg/m2,静脉滴注,于放疗前1d开始,1次/周,共4次;②给予6-mVX-线常规体外照射,1.8～2Gy/次,5次/周,总量50～60Gy/5～6周。结果初治患者有效率86.4%,复治患者有效率40%,总有效率68.8%,中位生存期10个月。不良反应:食管炎56.4%,白细胞减少46.4%,放射性肺炎17.6%。无治疗相关的病死。结论多西他赛同步放疗治疗老年晚期NSCLC疗效满意,耐受性好。 |
| 关 键 词： | 多西他赛 放射治疗 老年 非小细胞肺癌 |
| 修稿时间： | 2006-04-21 |
Concurrent taxotere and radiotherapy for elderly patients with advanced non-small cell lung cancer |
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| LIU Hai-yan,ZHANG Yan-ying,SONG Yan-mei. Concurrent taxotere and radiotherapy for elderly patients with advanced non-small cell lung cancer[J]. Practical Journal of Medicine & Pharmacy, 2006, 23(7): 786-788 | |
| Authors: | LIU Hai-yan ZHANG Yan-ying SONG Yan-mei |
| Affiliation: | LIU Hai-yan ZHANG Yan-ying SONG Yan-mei. Department of Oncology-Affiliated Hospital of Taishan Medical College Tai'an 271000 China |
| Abstract: | Objective To evaluate the therapeutic significance of concurrent taxotere and radiotherapy for elderly patients with advanced non-small cell lung cancer(NSCLC).Methods Elderly patients with advanced NSCLC received 6-MV X rays at split-course schedule with the total dose of 50-60Gy/5-6 weeks and taxotere-35mg/m2-administered on the first day of each radiotherapy week.Results Of 32 patients enrolled-the objective response occurred in 86.4% of chemo-navepatients and 40% of the others-the overall response rate was 68.8%.The media duration of survival was 8.5 months.The more frequent toxicities were esophagitis-leucopenia and pneumonitis (56.4%-46.4% and 17.6%-respectively).No serious toxicity and treatment related death occurred.Conclusion This regiment was well-tolerated and effective in elderly patients with advanced NSCLC. |
| Keywords: | Taxotere Radiotherapy Elder Non-small-cell lung cancer |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |