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| 异基因外周血干细胞移植治疗白血病9例临床分析 | |
| 引用本文： | 蓝梅,高清平,林金盈. 异基因外周血干细胞移植治疗白血病9例临床分析[J]. 内科, 2011, 6(4): 303-306 |
| 作者姓名： | 蓝梅 高清平 林金盈 |
| 作者单位： | 1. 武汉大学人民医院血液内科,湖北省武汉市,430060;广西壮族自治区人民医院血液内科,南宁市,530021 2. 武汉大学人民医院血液内科,湖北省武汉市,430060 3. 广西壮族自治区人民医院血液内科,南宁市,530021 |
| 摘 要： | 目的评价异基因外周血干细胞移植（Allo-PBSCT）治疗白血病的疗效及移植相关并发症。方法回顾分析9例白血病患者行同胞供者Allo-PBSCT治疗。预处理方案为改良马利兰加环磷酰胺（Bu／CY）；预防移植物抗宿主病（GVHD）采用环孢素A（CSA）加短程甲氨蝶呤（MTX）和霉酚酸酯（MMF）。结果8例患者均获得造血重建，白细胞植活的中位时间为15（13～16）d；1例未植入。出现GVHD7例，肝静脉闭塞病（HVOD）3例，出血性膀胱炎（HC）1例。中位随访时间为13（0～30）个月6例存活，其中5例为无病存活，3例死亡。结论Allo-PBSCT治疗白血病有效，移植相关并发症可接受。 |
| 关 键 词： | 白血病 外周血干细胞移植 异基因 并发症 |
Allogeneic Peripheral Blood Stem Cell Transplantation for treatment of leukemia in 9 patients |
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| LAN Mei,GAO Qing-ping,LIN Jin-ying. Allogeneic Peripheral Blood Stem Cell Transplantation for treatment of leukemia in 9 patients[J]. Internal Medicine of China, 2011, 6(4): 303-306 | |
| Authors: | LAN Mei GAO Qing-ping LIN Jin-ying |
| Affiliation: | 1 Department of Hematology, People＇s Hospital of Wuhan University, Wuhan 430060, China; 2 Department of Hematology,People＇s Hospital of GuangXi zhuang Autonomous Region,Nanning 530021, China) |
| Abstract: | Objective To explore the clinical effects and complications of allogeneic peripheral blood stem cell transplantation on the treatment of Leukemia.Methods The clinical data of 9 patients undergoing allo-PBSCT were analyzed retrospectively.The improved busulfan and cyclophosphamide(Bu/CY) were used as condition pretreatment regimen.Cyclosporine A(CsA) and short-course methotrexate(MTX) and mycophenlate mofetil(MMF) were administered to prevent the graft versus host disease(GVHD).Result 8 patients were engraft... |
| Keywords: | Leukemia Peripheral blood stem cell transplantation Allogeneic Complication |
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