原发性高血压患者血压晨峰对心脏结构和肾功能损伤的临床研究

目的探讨原发性高血压患者血压晨峰现象（MBPS）对心脏结构和肾功能的损害。方法根据24h动态血压监测结果，将符合条件的原发性高血压患者164例分为MBPS组（65例）和非MBPS组（99例）。常规检查空腹血糖、肌酐、血脂谱、尿微量白蛋白、a1微球蛋白、β2-微球蛋白等，计算体质量指数（BMI）、左室质量指数（LVMI）。结果MBPS组的24h、自昼、夜间平均收缩压、舒张压均显著高于非MBPS组动态血压监测水平（P〈0．05）。MBPS组的LVMI、尿微量白蛋白、a1微球蛋白、β2-微球蛋白均高于非MBPS组（P〈0．05）。结论原发性高血压晨峰者有更明显心脏结构和肾功能的损害。

Clinical Research on Damages of Morning Blood Pressure Surge of Hypertension on Cardiovascular Structures and Renal Functions

Objective To investigate the damages of morning blood pressure surge （ MBPS ） of hypertension patients on the cardiovascular structures and renal functions. Methods 164 patients were divided into MBPS group （ n=65 ） and non-MBPS group （ n=99 ） according to 24h ambulatory blood pressure monitoring. Body mass index （ BMI ） and left ventricular mass index （ LVMI ） were calculated, serum lipids profile, fasting blood glucose, creatinine, urinary microalbumin, α1-microglobulin, urinary β2 - microglobulin were examined. Results 24- hour, day and night systolic blood pressure and diastolic blood pressure in MBPS group were significantly higher than those in non-MBPS group （ P 〈 0.05 ） .LVMI, urinary microalbumin, α1- microglobulin, urinary β2 - microglobulin in MBPS group were higher than those in non- MBPS group （P〈0.05 ）. Conclusion The hypertension patients with MBPS were tended to suffer more damage of cardiac structures and renal