Demonstration of human papillomavirus types 6 and 11 in juvenile laryngeal papillomatosis by in-situ DNA hybridization |
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| Authors: | R M Terry F A Lewis S Griffiths M Wells C C Bird |
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| Institution: | Department of ENT Surgery, Bradford Royal Infirmary, U.K. |
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| Abstract: | A study is reported in which an in situ hybridization technique for the demonstration of human papillomavirus (HPV) employing a biotin--streptavidin polyalkaline phosphatase complex has been successfully applied to formalin-fixed paraffin-processed tissue obtained from ten patients with juvenile laryngeal papillomatosis. In all cases, positive results were obtained for either HPV type 6 or 11. Normal vocal cord epithelium was negative. |
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| Keywords: | Human papillomaviruses juvenile laryngeal papillomatosis DNA hybridization |
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