| 摘 要： | ![]()
PURPOSE： Most children with a diffuse intrinsic brainstem glioma will die within 1 year after diagnosis. To reduce patient burden, we investigated the feasibility of a radical hypofractionation radiotherapy schedule, given over 3 weeks, as an alternative to the standard regimen （30 fractions over 6 weeks）. METHODS AND MATERIALS： Nine children, ages 3-13, were treated by 13 fractions of 3 Gy （n = 8） or 6 fractions of 5.5 Gy （n = 1） given over 3 weeks. All patients had symptoms for ≤3 months and ≥2 signs of the neurologic triad （long tract signs, ataxia, cranial nerve deficit）. Bilateral involvement of the pons （n = 8）, encasement of the basilar artery （n = 7） and extension into the eerebellar peduncle （n = 6） was visible on magnetic resonance imaging.
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