| ACEI/ARB在心房颤动的预防治疗作用 |
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| 引用本文： | 王海云. ACEI/ARB在心房颤动的预防治疗作用[J]. 心血管病学进展, 2010, 31(4): 536-540. DOI: 10.3969/j.issn.1004-3934.2010.04.014 |
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| 作者姓名： | 王海云 |
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| 作者单位： | 首都医科大学,北京,100069 |
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| 基金项目： | 国家自然科学基金资助项目，首都医科大学附属北京安贞医院科研基金 |
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| 摘 要： | 心房颤动是临床上最常见的心律失常,并且很难治愈。目前,大家都把兴趣集中在针对发病机制的新治疗手段。近期研究提示,肾素-血管紧张素-醛固酮系统在心房颤动的发病机制中是一个非常重要的内分泌系统。因此,血管紧张素转换酶抑制剂和血管紧张素Ⅱ受体拮抗剂都成为了预防心房颤动的新型药物。现对血管紧张素转换酶抑制剂和血管紧张素Ⅱ受体拮抗剂在心房颤动治疗中所发挥的作用进行了讨论,并回顾了大量血管紧张素转换酶抑制剂和血管紧张素Ⅱ受体拮抗剂在高危心房颤动人群（如心力衰竭、高血压、心肌梗死等）的临床研究。
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| 关 键 词： | 心房颤动 血管紧张素转换酶抑制剂 血管紧张素Ⅱ受体拮抗剂 |
ACEI and ARB in Prevention of Atrial Fibrillation |
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| WANG Hai-yun. ACEI and ARB in Prevention of Atrial Fibrillation[J]. Advances in Cardiovascular Diseases, 2010, 31(4): 536-540. DOI: 10.3969/j.issn.1004-3934.2010.04.014 |
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| Authors: | WANG Hai-yun |
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| Affiliation: | WANG Hai-yun,LIU Xiao-hui(1.Seven-year Student of Capital Medical University,Beijing 100069,China;2.The Second Department of Cardiology,Beijing Anzhen Hospital Affiliated to Capital Medical University,Beijing 100029,China) |
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| Abstract: | Atrial fibrillation（AF） is the most common clinical arrhythmia.AF is also difficult to treat.Therefore,there is increasing interest in novel therapeutic approaches that target AF-substrate development.Recent trials suggest that the renin-angiotensin-aldosterone system（RAAS） has emerged as an important hormonal system in the initiation and pathogenesis of AF.Due to this angiotensin-converting enzyme inhibitors（ACEI） or angiotensin receptor blockers（ARB） are emerging as novel drugs for the prevention of AF.The present article will discuss information pertaining to the clinical use of ACEI and ARB in AF.It will also review the current data on the use of ACEIs and ARBs in a high-risk group of AF patients. |
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| Keywords: | atrial fibrillation angiotensin-converting enzyme inhibitors angiotensin receptor blockers |
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