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| Effects of Anti-CD59 on Complement- induced Platelet Activation in Adult Males with Coronary Heart Disease | |
| 引用本文： | 王礼春,马虹,黄守坚,麦炜颐,董吁钢,曾武涛,廖新学,何建桂,徐冬. Effects of Anti-CD59 on Complement- induced Platelet Activation in Adult Males with Coronary Heart Disease[J]. 岭南心血管病杂志(英文版), 2003, 4(1): 5-7 |
| 作者姓名： | 王礼春 马虹 黄守坚 麦炜颐 董吁钢 曾武涛 廖新学 何建桂 徐冬 |
| 作者单位： | The cardiovascular department of the first affiliated hospital of Zhongshan university，Guanzhou 510080，P R China，The cardiovascular department of the first affiliated hospital of Zhongshan university，Guanzhou 510080，P R China，The pharmacological department of Zhongshan university，Guangzhou 510080，P R China，The cardiovascular department of the first affiliated hospital of Zhongshan university Guangzhou 510080，P R China，The cardiovascular department of the first affiliated hospital of Zhongshan university Guangzhou 510080，P R China，The cardiovascular department of the first affiliated hospital of Zhongshan university Guangzhou 510080，P R China，The cardiovascular department of the first affiliated hospital of Zhongshan university Guangzhou 510080，P R China，The cardiovascular department of the first affiliated hospital of Zhongshan university Guangzhou 510080，P R China，The pharmacological department of Zhongshan university，Guangzhou 510080，P R China |
| 摘 要： | INTRoDUCTIoN The abnormal activation of platelet takes Dart in the process of coronary heart disease.Besides improv.ing artery arteriosclerosis,the activation of platelet plays an important role in acute coronary syndrome,ischemic and reperfusion injury and restenosis after coronary artery angioplasty.Many studies indicate that active complement components can induce platelet ac。tivation.And some pathophysiologic changes andtreatments in CHD,such as the injury of endothelial cell,myocar… |
| 关 键 词： | 冠心病 CD59 血小板活化 成年男性 |
Effects of Anti - CD59 on Complement - induced Platelet Activation in Adult Males with Coronary Heart Disease |
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| WANG Lichun,MA Hong HUANG Shoujian MAI Weiyi DONG Yugang,ZENG Wutao,LIAO Xinxue,He JianguiXU DongThe cardiovascular. Effects of Anti - CD59 on Complement - induced Platelet Activation in Adult Males with Coronary Heart Disease[J]. South China Journal of Cardiology, 2003, 4(1): 5-7 | |
| Authors: | WANG Lichun MA Hong HUANG Shoujian MAI Weiyi DONG Yugang ZENG Wutao LIAO Xinxue He JianguiXU DongThe cardiovascular |
| Affiliation: | WANG Lichun,MA Hong HUANG Shoujian MAI Weiyi DONG Yugang,ZENG Wutao,LIAO Xinxue,He JianguiXU DongThe cardiovascular department of the fint affiliated hospital of Zhongshan university Guangzhou 510080,P R China The pharmacological department of Zhongshan university,Guangzhou 510080,P R China |
| Abstract: | Objectives To study the reactions of platelet to active complement and the effects of anti - CD59 on platelet activation induced by complement in coronary heart disease (CHD) adult males. Methods By applying cobra venom factor (CVF) to activate complement, observed the platelet aggregation and release reactions induced by active complement with or without applying anti - CD59 to block the complement modulation protein CD59. Results CVF could induce platelet of CHD individuals release ATP and cause significant and lasting metamorphosis, but failed to induce platelet aggregate. The platelet maximum shape change showed positive linear correlation with lg concentration of CVF. The regressive equation was Y= 28. 7171gx - 19. 798 ( r = 0.956, P <0. 01, n = 36). Anti - CD59 could enhance CVF - induced platelet shape change and ATP release with a dose - dependent manner. Conclusions Complement activated by CVF can induce significant and lasting platelet metamorphosis and release reaction, but can't induce platelet aggregation in CHD adult males. Anti - CD59 can promote the platelet reactions induced by active complement. |
| Keywords: | Complement Platelet Anti -CD59 Coronary heart disease |
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