| Effects of AT1 Antagonist on MMP2, MMP9 Expression and Collagen Remodeling in Left Ventricle of Rabbit Undergoing Chronic Pressure Overload |
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| 作者姓名： | 王军奎 崔长琮 姚青海 姚晓伟 崔翰斌 |
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| 作者单位： | DepartmentofCardiology,TheFirstHospital,Xi‘anJiaotongUniversity,Xi’an710061,PRChina |
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| 摘 要： | Objectives To study the effects of AT1 antagonist on MMP2, MMP9 expression and collagen remodeling in left ventricle of rabbit undergoing chronic pressure overload. Methods 30 rabbits were randomly divided into 3 groups (n= 10,each group), including sham operation group, abdominal aorta banded group(banded group), abdominal aorta banded valsartan group (valsartan group).Twelve weeks after operation,hemodynamic parame-ters were acquired, then collagen volume fraction(CVF) and MMP2, MMP9 expression of left ventricle were measured by using VG and immunohistochemical stain. Results Compared with sham operation group, both MMP2 and MMP9 expression were enhanced in banded group; meanwhile, LVW/BW,LVEDP and CVF increased significantly. Compared with banded group, both MMP2 and MMP9 expression were weakened in valarstan group; simultaneously,LVW/BW, LVEDP and CVF decreased significantly.Conclusions Expression of MMP2 and MMP9 was enhanced in left ventricle of rabbit undergoing chronic pressure overload, which may be associated with collagen proliferation, ventricule remodeling and impaired heart function; Valsartan could inhibit collagen proliferation, prevent ventricule remodeling and preserve heart function by inhibiting abnormal expression of MMP2 and MMP9.
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| 关 键 词： | 缬沙坦 金属基质蛋白-2 金属基质蛋白-9 胶原质 左心室 心脏疾病 |
Effects of AT1 Antagonist on MMP2, MMP9 Expression and Collagen Remodeling in Left Ventricle of Rabbit Undergoing Chronic Pressure Overload |
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| WANG Junkui,CUI Changcong,YAO Qinghai YAO Xiaowei
CUI Hanbin.Effects of AT1 Antagonist on MMP2, MMP9 Expression and Collagen Remodeling in Left Ventricle of Rabbit Undergoing Chronic Pressure Overload[J].South China Journal of Cardiology,2003,4(1):55-58,62. |
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| Authors: | WANG Junkui CUI Changcong YAO Qinghai YAO Xiaowei
CUI Hanbin |
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| Institution: | WANG Junkui,CUI Changcong,YAO Qinghai YAO Xiaowei
CUI Hanbin
Department of Cardiology,The First Hospital,Xi'an Jiaotong University,Xi'an 710061,P R China |
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| Abstract: | Objectives To study the effects of AT1 antagonist on MMP2, MMP9 expression and collagen remodeling in left ventricle of rabbit undergoing chronic pressure overload. Methods 30 rabbits were randomly divided into 3 groups ( n = 10, each group), including sham operation group, abdominal aorta banded group (banded group), abdominal aorta banded +valsartan group (valsartan group). Twelve weeks after operation, hemodynamic parameters were acquired, then collagen volume fraction (CVF) and MMP2, MMP9 expression of left ventricle were measured by using VG and immunohistochemical stain. Results Compared with sham operation group, both MMP2 and MMP9 expression were enhanced in banded group; meanwhile, LVW/BW, LVEDP and CVF increased significantly. Compared with banded group, both MMP2 and MMP9 expression were weakened in valarstan group; simultaneously, LVW/BW, LVEDP and CVF decreased significantly. Conclusions Expression of MMP2 and MMP9 was enhanced in left ventricle of rabbit undergoing chronic pressure overload, which may be associated with collagen proliferation, ventricule remodeling and impaired heart function; Valsartan could inhibit collagen proliferation, prevent ventricule remodeling and preserve heart function by inhibiting abnormal expression of MMP2 and MMP9. |
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| Keywords: | Valsartan Collagen fibers Ventricule remodeling Matrix metalloprotinases |
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