牛磺酸对铅染毒大鼠大脑皮层NOS和nNOS神经元数量的影响

目的 探讨牛磺酸拮抗铅损害中枢神经系统的作用，研究牛磺酸拮抗铅的剂量-效应关系。方法 采用黄递酶（NADPH-d）组织化学和神经元型一氧化氮合酶（nNOS）免疫组织化学方法，研究饮用含不同剂量醋酸铅（0．02，0．2g／L）饮水和饲喂含不同剂量牛磺酸（5，10g／kg）饲料的大鼠大脑皮层NOS和nNOS阳性神经元数量的变化。结果 牛磺酸能明显增加铅染毒大鼠大脑皮层NOS和nNOS阳性神经元的数量。结论 牛磺酸对铅损害中枢神经系统有较明显的拮抗作用，并且存在一定的剂量-效应关系。

Changes of NOS and nNOS Positive Neuron Quantity in Cortex of Lead Exposed Rats

Objective To probe into antagonsim of taurine against harmful effects of Pb on NOS and nNOS positive neurons in cortex and its dose-effect relationship.Methods The experiment rat groups were fed with different dosages of lead acetate water solution(0.02,and 0.2 g/L)and different dosages of taurine(5,and 10 g/kg).The changes of NOS and nNOS positive neurons in cortex were observed by NADPH-d histochemistry method.Results Taurine could obviously increase NADPH-d and nNOS positive neurons quantity in cortex of Pb exposed rats.Conclusions Taurine could resist the harmful effects of Pb on nervous system,and show dose-effect relationship.