Role of B cells in systemic lupus erythematosus and rheumatoid arthritis |
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Authors: | Mandik-Nayak Laura Ridge Natalie Fields Michele Park Audrey Y Erikson Jan |
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Affiliation: | Lankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, PA 19096, United States. Mandik-Nayakl@mlhs.org |
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Abstract: | B cell tolerance to many self-proteins is actively maintained by either purging self-reactive B receptors through clonal deletion and receptor editing, or by functional silencing known as anergy. However, these processes are clearly incomplete as B cell driven autoimmune diseases still occur. The significance of B cells in two such diseases, rheumatoid arthritis and systemic lupus erythematosus, is highlighted by the ameliorative effects of B cell depletion. It remains to be determined, however, whether the key role of the B cell in autoimmune disease is autoantibody production or another antibody-independent function. |
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