| 拟胆碱莨菪烷类生物碱的合成及其生物活性 |
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| 引用本文： | 丁维功,杨丽敏,于月梅. 拟胆碱莨菪烷类生物碱的合成及其生物活性[J]. 药学学报, 1993, 28(4): 302-306 |
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| 作者姓名： | 丁维功 杨丽敏 于月梅 |
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| 作者单位： | 上海第二医科大学化学教研室，上海第二医科大学化学教研室，上海第二医科大学化学教研室 上海 200025，上海 200025，上海 200025 |
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| 摘 要： | ![]()
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| 关 键 词： | 包公藤甲素类似物 拟胆碱莨菪烷 拟胆碱活性 |
| 收稿时间： | 1992-05-04 |
THE SYNTHESIS AND BIOACTIVITIES OF CHOLINERGIC TROPANE ALKALOIDS |
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| WG Ding,LM Yang and YM Yu. THE SYNTHESIS AND BIOACTIVITIES OF CHOLINERGIC TROPANE ALKALOIDS[J]. Acta pharmaceutica Sinica, 1993, 28(4): 302-306 |
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| Authors: | WG Ding LM Yang YM Yu |
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| Abstract: | ![]()
Ten analogs of baogongteng A, the natural cholinergic tropane alkaloid isolated from Erycibe obtusifolia Benth, were designed and synthesized. The tropane skeleton was kept unchanged, while the substituting groups on N and C_3 were modified. In myotic experiments in rabbits 3-paramethyl benzoyloxy- 6-acetoxy nortropane (4), 3-propionyloxy- 6-acetoxy nortropane (5), and 3-isobutyryloxy-6-acetoxy nortropane(6) showed cholinergic activities. |
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| Keywords: | Analogs of baogongteng A Cholinergie tropane Cholinergie activities |
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