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Effect of beta blockade on plasma catecholamine levels during psychological and exercise stress |
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| Authors: | Joel E. Dimsdale L.Howard Hartley Jeremy Ruskin David J. Greenblatt Richard LaBrie |
| Affiliation: | 1. From the Department of Psychiatry, Harvard Medical School, Massachusetts General HospitalUSA;2. Department of Cardiology, Harvard Medical School, Brigham and Womens HospitalUSA;3. Department of Cardiology, Massachusetts General HospitalUSA;4. Division of Clinical Pharmacology, Tufts University School of Medicine and New England Medical Center Hospital, Boston, USA;5. LaBrie Associates, Inc., Cambridge, Massachusetts, USA |
| Abstract: | The effect of a single oral dose of 50 mg of metoprolol on plasma catecholamine levels was examined in 11 healthy young men. Subjects were studied during baseline at rest, postural challenge, psychological Stressors and graded maximal exercise testing. Metoprolol induced significant increases in plasma norepinephrine (NE) levels across most experimental conditions. Metoprolol did not have a consistent effect on plasma epinephrine levels. Because of wide interindividual variation in drug levels, the NE levels in subjects with high drug levels were compared with the NE levels in subjects who had negligible drug levels. NE levels were higher in subjects with higher drug levels. |
| Keywords: | Address for reprints: Joel E. Dimsdale MD Department of Psychiatry Harvard Medical School Massachusetts General Hospital Boston Massachusetts 02114. |
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