| 盐酸左氧氟沙星注射液在不同pH值液体中的稳定性研究 |
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| 引用本文： | 吴洲,武风云. 盐酸左氧氟沙星注射液在不同pH值液体中的稳定性研究[J]. 黑龙江医学, 2007, 31(5): 360-360 |
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| 作者姓名： | 吴洲 武风云 |
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| 作者单位： | 安阳钢铁集团公司职工总医院药剂科,河南,安阳,455000;安阳钢铁集团公司职工总医院药剂科,河南,安阳,455000 |
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| 摘 要： | 目的观察盐酸左氧氟沙星注射液在不同pH值液体中的稳定性,为临床合理选择大输液及相关药物的配伍禁忌提供依据。方法配制一系列不同pH值的葡萄糖注射液、氯化钠注射液,加入盐酸左氧氟沙星,观察溶液的稳定性。结果溶液pH在6.4以下稳定,在6.4～7.6之间部分出现浑浊,在7.6以上容易析出结晶。结论配制含盐酸左氧氟沙星的输液宜选用偏酸性的葡萄糖注射液,不宜选择偏中性的氯化钠注射液,避免和碱性药物配伍。
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| 关 键 词： | 盐酸左氧氟沙星 pH值 配伍 稳定性 |
| 文章编号： | 1004-5775（2007）05-0360-01 |
| 修稿时间： | 2007-03-06 |
Study of Levofloxacin Stability in Varied pH Fluid |
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| WU Zhou,WU Feng-yun. Study of Levofloxacin Stability in Varied pH Fluid[J]. Heilongjiang Medical Journal, 2007, 31(5): 360-360 |
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| Authors: | WU Zhou WU Feng-yun |
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| Affiliation: | Department of Parmacy, The General StaffHospital of Steel Group Company of Anyang, Henan 455000, China |
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| Abstract: | Objective To study the stability of levofloxacin chloride injection in varied pH fluid In order to supply the reasonable choice and the evidence of relative drug incompatibility.Methods The varied pH value of glucose and saline were added levofloxacin chloride and the stability was observed.Results The solution was stable below pH 6.4,tubid at 6.4～7.6 and crystal over 7.6.Conclusion The acid-like glucose fluid might be better for levofloxacin than other saline solution to avoid alkaline solution. |
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| Keywords: | Levofloxacin chloride pH value Compatibility Stability |
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