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Effects of Captopril and Nadolol on Renal Hemodynamics in Patients with Essential Hypertension
引用本文:朱忠华,安锐,张永学,龚培力,陈汇,曾繁典. Effects of Captopril and Nadolol on Renal Hemodynamics in Patients with Essential Hypertension[J]. 华中科技大学学报(医学英德文版), 1994, 14(1): 45-48. DOI: 10.1007/BF02888058
作者姓名:朱忠华  安锐  张永学  龚培力  陈汇  曾繁典
作者单位:ZHU Zhong-hua(Department of Nephrology,Xiehe Hospital,Tongji Medical University,Wuhan)AN Rui,ZHANG Yong-xue(Department of Nuclear Medicine,Xiehe Hospital,Tongji Medical Universty,Wuhan)GONG Pei-li,CHEN Hui,ZEN Fan-dian (Department of Clinical Pharmacology
摘    要:(朱忠华)(安锐)(张永学)(龚培力)(陈汇)(曾繁典)EffectsofCaptoprilandNadololonRenalHemodynamicsinPatientswithEssentialHypertension¥ZHUZhong-hua(D...

收稿时间:1993-09-14

Effects of captopril and nadolol on renal hemodynamics in patients with essential hypertension
Zhu Zhong-hua,An Rui,Zhang Yong-xue,Gong Pei-li,Chen Hui,Zen Fan-dian. Effects of captopril and nadolol on renal hemodynamics in patients with essential hypertension[J]. Journal of Huazhong University of Science and Technology. Medical sciences, 1994, 14(1): 45-48. DOI: 10.1007/BF02888058
Authors:Zhu Zhong-hua  An Rui  Zhang Yong-xue  Gong Pei-li  Chen Hui  Zen Fan-dian
Affiliation:(1) Department of Nephrology, Xiehe Hospital, Tongji Medical University, Wuhan;(2) Department of Nuclear Medicine, Xiehe Hospital, Tongji Medical University, Wuhan;(3) Department of Clinical Pharmacology, Tongji Medical University, Wuhan
Abstract:The randomized single-blind study was designed to compare the effects of captopril Cap),and nadolol(And)on renal hemodynamics in 60 patients with essential hyperttnsion.They were divided into two groups at random.Cap was given in dosage of 37.5-75 mg/d per os and And 40-80 mg/d.The results show that both drugs increase the blood volume distributed to the kidneys from cardiac output(renal blood flow/cardiac output),Cap increasing 10% (P<0. 05) and And 8%(F<0.05) Renal vascular resistance(RVR)is lowered by the two drugs,13%(P<0. 05) by Cap and 11%(P<0.05) by And.These suggest that both drugs facilitate the maintenance of renal blood circulation in patients with essential hypeitension.being beneficial for long-term treatment of hypertension.
Keywords:captopril  nadolol:essential hypertension  renal hemodynamics  systemic hemodynamics
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