脑出血术后脑脊液中食管癌相关基因4和S100B蛋白表达水平与GCS评分及Barthel指数的相关性研究

目的 探讨脑出血(intracerebral hemorrhage,ICH)患者术后脑脊液(CSF)中食管癌相关基因4(ECRG4)与S100钙结合蛋白B(S100B)表达水平与格拉斯哥昏迷评分(Glasgow coma scale,GCS)和巴氏指数(barthel index,BI)的相关性,及其在脑出血患者术后神...

Expression Level of Esophageal Cancer-Related Gene 4 and S100B Protein in Cerebrospinal Fluid after Intracerebral Hemorrhage and Its Correlation with GCS Score and Barthel Index

Objective To investigate the correlation between the expression levels of ECRG4 and S100B protein in CSF and Glasgow coma scale(GCS),barthel index(BI)in patients with intracerebral hemorrhage(ICH)after operation,and its clinical application value in the rehabilitation of neurological function after operation of cerebral hemorrhage.Methods The levels of ECRG4 and S100B protein were detected by enzyme-linked immunosorbent assay(ELISA)in 10 cases of control group,10 cases of lumbar cistern drainage group and 10 cases of lumbar puncture group.GCS and BI scores were performed,and the correlation was analyzed.Results On day 7 after operation,ECRG4 in control group(1.14±0.39 pg/ml)was lower than that in drainage group(15.50±0.28 pg/ml)and puncture group(10.71±0.89 pg/ml),S100B in control group(0.550±0.310 ng/ml)was higher than that in drainage group(0.154±0.025ng/ml)and in puncture group(0.192±0.030 ng/ml),and there was significant difference among the groups(t=11.630,28.120,P<0.05).The GCS and BI of drainage group(11.62±1.71,10.19±1.41)and puncture group(43.24±10.05,40.64±10.10)were significantly higher than those of control group(GCS:7.07±1.43,BI:21.73±6.45),the difference was statistically significant(t=7.466,4.180,P<0.05).Conclusion The change trend of ECRG4 and S100B protein in cerebrospinal fluid of patients with intracerebral hemorrhage were positively correlated with GCS and BI.The combined detection of two indicators is helpful to adjust the treatment plan,so as to reduce the occurrence of neurological dysfunction and improve the prognosis.