血清C-反应蛋白和内皮素水平检测与急性胆囊炎临床分级的相关性分析

目的 探究血清C-反应蛋白(C-reactive protein,CRP)、内皮素(endothelin,ET)水平检测与急性胆囊炎(acute cholecystitis,AC)临床分级的相关性.方法 选取汉中市中心医院2017年3月～2019年11月收治的110例AC患者为观察组,另选取同期110例健康体检者为对照...

Correlation Analysis of Serum C-reactive Protein and Endothelin Levels with Clinical Grade of Acute Cholecystitis

Objective To explore the correlation between serum C-reactive protein(CRP)and endothelin(ET)levels and the clinical grade of acute cholecystitis(AC).Methods A total of 110 AC patients admitted to Hanzhong Central Hospital from March 2017 to November 2019 were selected as the observation group,and 110 healthy physical check-up patients in the same period were selected as the control group.General data on smoking,alcohol consumption,hypertension,CRP and ET levels in the two groups were collected respectively.The levels of CRP and ET in human serum were measured by ELISA and radioimmunoassay(RIA).Spearson correlation test was used to analyze the correlation between CRP,ET and AC clinical grading.Results There were no statistically significant differences in gender,average age,smoking,alcohol consumption,hypertension or diabetes between the two groups((χ²/t=1.640,0.428,3.160,4.250,3.570,3.660,all P>0.05).The difference of CRP and ET levels between the two groups was statistically significant(t=9.629,7.374,all P<0.05),and the CRP and ET levels of patients in the observation group were significantly higher than those in the control group.In ROC curve analysis,the AUC of CRP,ET and the combined diagnosis of AC was 0.843(95%CI:0.771~0.916,P=0.000),0.772(95%CI:0.683~0.860,P=0.000)and 0.910(95%CI:0.851~0.969,P=0.000),respectively,the maximum value of the Jordan index corresponding to CRP and ET were 8.2 mg/L and 72.5 pg/ml,respectively,and the sensitivity and specificity of CRP and ET in the combined diagnosis of AC were higher than that of CRP and ET alone.CRP and ET were positively correlated with AC grading(r=0.386,P<0.05).Conclusion The combined levels of CRP and ET can distinguish AC with different degrees of severity,and the combined levels of CRP and ET are positively correlated with AC grading,which is worthy of further study and application.