Fat-Free Mass Depletion and Inflammation in Patients with Bronchiectasis |
| |
| Authors: | Gabriel Olveira Casilda Olveira Inmaculada Gaspar Nuria Porras Gracia Martín-Núñez Elehazara Rubio Natalia Colomo Gemma Rojo-Martínez Federico Soriguer |
| |
| Affiliation: | 1. Service d''endocrinologie, diabète et nutrition, Hôpitaux Universitaires de Strasbourg, place de l''hôpital, Strasbourg 67091, France;2. Service de pneumologie et CRCM adulte, Hôpitaux Universitaires de Strasbourg, 1 place de l''hôpital, Strasbourg 67091, France;3. Department of Internal Medicine Adult Cystic Fibrosis Care Center, Hospices Civils de Lyon, Université Claude Bernard Lyon 1, France, EA HESPER, Lyon 7425, France;4. Pôle de Santé Publique, Hospices Civils de Lyon, France, Université Claude Bernard Lyon 1, EA HESPER, Lyon 7425, France;5. CRCM, Hôpitaux Universitaires de Reims, 47, rue Cognacq-Jay, Reims 51092, France;6. Centre de Giens, Hospices Civils de Lyon, Lyon, France;7. CRCM, CHU Rouen, Rouen, France;8. CRCM Angers-Le Mans, CHU Angers, Angers, France;9. CRCM, CHU Marseille, Marseille, France;10. CRCM enfant, Hôpital Robert Debré, Paris, France;11. CRCM, Hôpital Bretonneau, CHRU Tours, Tours, France;12. CRCM, Hôpital de Clocheville, CHRU Tours, Tours, France;13. CRCM, Raphael Chiron, Hôpital Arnaud de Villeneuve, Montpellier, France;14. CRCM pédiatrique, Hôpitaux Universitaires de Strasbourg, 1 Avenue Molière, Strasbourg 67098, France;15. Inserm UMR 1260 Regenerative Nanomedicine Fédération de Médecine Translationnelle, Université de Strasbourg, Strasbourg, France;1. Department of Paediatrics, Cystic Fibrosis Center, Fondazione IRCCS Ca'' Granda Ospedale Maggiore Policlinico, University of Milan, Italy;2. International Center for the Assessment of Nutritional Status, University of Milan, Milan, Italy;3. Bone Metabolism Unit, Istituto Auxologico Italiano IRCCS, Milan, Italy |
| |
| Abstract: | Fat-free mass depletion has been related to increased inflammatory activity and to increased morbidity and mortality in chronic respiratory diseases. The aims of our study were to determine the nutritional status and serum levels of adipocytokines and inflammatory cytokines in patients with bronchiectasis of any etiology and their relation with respiratory parameters. A cross-sectional study was designed that included patients aged >14 years with diagnostic criteria for bronchiectasis. Anthropometric parameters; a diet questionnaire; hand grip dynamometry; levels of leptin, adiponectin, interleukin-6 (IL-6), tumor necrosis factor-α, and ultrasensitive C-reactive protein; as well as respiratory parameters (ie, clinical, radiologic, and spirometric values) were assessed. Ninety-three clinically stable patients were recruited, 43 with cystic fibrosis, 31 with noncystic fibrosis bronchiectasis, and 19 with cystic fibrosis transmembrane conductance regulator-related bronchiectasis. Fat-free mass depletion was present in 31% of patients, with no differences according to the etiology of the bronchiectasis. Correlations were found between inflammatory cytokines (ie, IL-6) and exacerbations, bronchorrea, forced expiratory volume in 1 second, and Bhalla score. Patients with worse respiratory disease severity, malnutrition, and diabetes had significantly higher levels of IL-6. Adiponectin correlated significantly and positively with fat mass and fat mass index and negatively with fat-free mass, fat-free mass index, and hand dynamometry. Leptin correlated positively with body mass index, fat mass and fat mass index, and negatively with fat-free mass, fat-free mass index, and dynamometry. Patients with bronchiectasis present a high percentage of fat-free mass depletion, independent of the etiology of the disease. The levels of inflammatory cytokines (especially IL-6) may be useful markers of disease severity. Adiponectin levels were higher in patients with fat-free mass depletion. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
