Deep insight into white spot syndrome virus vaccines: A review |
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| Authors: | MA Badhul Haq R Vignesh M Srinivasan |
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| Affiliation: | 1. The National Lobster Hatchery, Padstow, Cornwall, UK;2. Aquaculture and Fish Nutrition Research Group, School of Biomedical and Biological Sciences, Plymouth University, Devon, UK;3. Norwegian College of Fishery Science, Faculty of Biosciences, Fisheries and Economics, University of Tromsø, Tromsø, Norway;1. Department of Biotechnology, Faculty of Science, Mahidol University, Rama VI Rd., Bangkok 10400, Thailand;2. Center of Excellence for Shrimp Molecular Biology and Biotechnology, Faculty of Science, Mahidol University, Rama VI Rd., Bangkok 10400, Thailand;3. Shrimp–Virus Interaction Laboratory (ASVI), National Center for Genetic Engineering and Biotechnology (BIOTEC), Yothi Office, Rama VI Rd., Bangkok 10400, Thailand;4. Department of Biochemistry, Faculty of Science, Mahidol University, Rama VI Rd., Bangkok 10400, Thailand;5. National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Thailand Science Park, Pathumthani 12120, Thailand |
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| Abstract: | White spot syndrome virus (WSSV), the causative virus of the disease, is found in most shrimp farming areas of the world, where it causes large economic losses to the shrimp farming industry. The potentially fatal virus has been found to be a threat not only to all shrimp species, but also to other marine and freshwater crustaceans, such as crab and crayfish. To date, no effective prophylactic treatment measures are available for viral infections in shrimp and other crustaceans. Due to current aquaculture practices and the broad host range of WSSV, intervention strategies including vaccination against this virus would be pivotal to save and protect shrimp farming. Several achievements have been attained in the search of novel vaccines for WSSV. DNA vaccination, recombinant vaccines, oral vaccination techniques and gene therapy are some of the thrust areas of focus for scientists and researchers. This review article highlights the recent trends in the development of WSSV vaccines either as DNA vaccines or recombinant vaccines and their functioning strategies as suggested by the researchers worldwide. |
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