血清PLGF和sFLT-1水平联合检测对急性ST段抬高型心肌梗死患者PCI术后MACE复发的诊断价值研究

目的 探讨血清胎盘生长因子(PLGF)和可溶性fms样酪氨酸激酶-1(sFLT-1)在急性ST段抬高型心肌梗死(ST-AMI)患者经皮冠状动脉介入治疗(PCI)后心血管不良事件(MACE)复发中的价值.方法 选取2018年1月～2019年1月收治的ST-AMI患者230例作为研究对象,入院后均及时进行PCI治疗,入院后...

Combined Detection of Serum PLGF and SFLT-1 Levels in the Diagnosis of MACE Recurrence after PCI in Patients with Acute ST-segment Elevation Myocardial Infarction

Objective To explore the diagnostic value of serum placental growth factor(PLGF)and soluble fms-like tyrosine kinase-1(SFLT-1)levels in the recurrence of major adverse cardiovascular events(MACE)after the percutaneous coronary intervention(PCI)in patients with acute ST-segment elevation myocardial infarction(ST-AMI).Methods A number of 230 patients with ST-AMI admitted from January 2018 to January 2019 in Yuebei People’s Hospital were included.The PCI treatment was performed in time and remission was achieved within 12 days after admission.The venous blood was collected on the 12th day on a fasting stomach and serum was separated.The patients were followed up for one year and divided into the MACE group(68 cases)and the control group(162 cases)according to their MACE recurrence.The difference of serum PLGF and SFLT-1 concentrations and the MACE diagnostic value between the two groups were compared.Results The serum PLGF level in the MACE group(22.56±5.99 pg/ml)was significantly lower than that of the control group(32.71±7.90 pg/ml)(t=10.57,P<0.0001).The serum SFLT-1 level in the MACE group(189.58±69.94 pg/ml)was significantly higher than that of the control group(141.52±59.76 pg/ml)(t=5.372,P<0.0001).The sensitivity,specificity,and AUROC of serum PLGF and SFLT-1 levels were 80.25%,53.47%,0.766 and 74.07%,58.82%,0.697,respectively.The sensitivity,specificity,and AUROC of the combined detection of serum PLGF and sFLT-1 were 77.90%,72.8%and 0.820,respectively.Conclusion Serum PLGF and SFLT-1 can be used for early diagnosis of MACE recurrence after PCI in ST-AMI patients,and combined detection has higher sensitivity and specificity.