Antidiabetic and antioxidant potentials of spent turmeric oleoresin,a by-product from curcumin production industry |
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| Authors: | Suresh V Nampoothiri PC Lekshmi VV Venugopalan A Nirmala Menon |
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| Affiliation: | 1. Department of Chemistry, Indian Institute of Space Science and Technology (IIST), Valiamala, Thiruvananthapuram, Kerala 695 547, India;2. Indian Institute of Science Education and Research Bhopal, Bhauri, Madhya Pradesh 462 066, India;3. Tissue Culture Laboratory, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Poojappura, Thiruvananthapuram, Kerala 695 012, India;1. School of Pharmacy, Bandung Institute of Technology, Bandung Jl. Ganesa No. 10 Bandung 40132, Indonesia;2. Hasan Sadikin Hospital, Bandung, Teaching Hospital of University Padjadjaran Bandung, Indonesia;1. Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran, Iran;2. Department of Endocrinology, Tehran University of Medical Sciences, Tehran, Iran;3. Department of Pharmacotherapy, School of Pharmacy, Shiraz University of Medical Sciences, P.O. Box 1583, Shiraz, Iran;4. University Hospital Center Zagreb, Department of Internal medicine, University of Zagreb School of Medicine, Ki?pati?eva 12, Zagreb, Croatia;5. Sabinsa Corporation, East Windsor, NJ, United States;6. Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;1. College of Nursing, King Saud University, Riyadh, Saudi Arabia;2. College of Education, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia;3. Medicinal, Aromatic and Poisonous Plants Research Center (MAPRC), College of Pharmacy, King Saud University, Riyadh, Saudi Arabia;1. Department of Food Science and Technology, State University of Londrina, 86057-970, Londrina, Brazil;2. Department of Chemistry, State University of Londrina, 86057-970, Londrina, Brazil;3. Department of Microbiology, State University of Londrina, 86057-970, Londrina, Brazil;4. Laboratory of Electron Microscopy and Microanalysis, State University of Londrina, 86057-970, Londrina, Brazil |
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| Abstract: | ![]()
ObjectiveTo investigate the antidiabetic and antioxidant activity of spent turmeric oleoresin (STO).MethodsAntidiabetic activity of STO evaluated by α-amylase and α-glucosidase enzyme inhibition assays. The antioxidant capacity studied by DPPH., ABTS., superoxide radical scavenging and metal chelating activity methods.ResultsThe STO showed good antidiabetic activity by inhibiting key enzymes linked to type 2 diabetes, viz α-glucosidase and α-amylase with an IC50values of 0.71 and 0.16μg/mL respectively. The IC50values for DPPH. and ABTS. assay were 58.1 and 33 μg/mL respectively. STO effectively scavenged the superoxide free radical with an IC50 value of 61.5μg/mL and showed a moderate iron chelation property.ConclusionsThe above study reveals that the spent turmeric oleoresin being wasted at present can be used as antioxidant and antidiabetic agent in food and neutraceutical products. |
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