Expression of nicotinic acetylcholine receptor mRNA in the adult rat peripheral vestibular system |
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| Authors: | Hakim Hiel Ana B. Elgoyhen Dennis G. Drescher Barbara J. Morley |
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| Affiliation: | aNeurochemistry Laboratory, Boys Town National Research Hospital, 555 North 30th Str., Omaha, NE 68131, USA;bInstituto de Investigaciones Farmacologicas (CONICET), Buenos Aires 1113, Argentina;cLaboratory of Bio-Otology, Wayne State University Medical School, Detroit, MI 48201, USA |
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| Abstract: | ![]()
The mRNA expression of the neuronal nicotinic acetylcholine receptor subunits was determined in adult rat vestibular end-organs and in Scarpa's ganglion (SCG) by in situ hybridization with [35S]riboprobes. Neurons in the SCG expressed the α4–7 and β2–3 mRNAs, but not α3 or β4 mRNAs. Not all SCG neurons expressed every mRNA found in SCG. The α6 and β2–3 riboprobes labeled all neurons, but α4, α5, and α7 mRNAs were selectively expressed in one or more subpopulations of SCG neurons. Vestibular sensory hair cells, in contrast, expressed only a9 mRNA. |
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| Keywords: | Vestibular Efferent Hybridization, in situ Hair cell Nicotinic acetylcholine receptor Scarpa's ganglion |
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