Fe-Fe3O4核壳结构纳米材料的制备与表征

目的通过还原－氧化方法使作为前躯体的Fe3O4纳米颗粒具有Fe－Fe3O4核壳结构，以作为磁靶向药物载体。方法在管式炉中以H2还原Fe3O4纳米颗粒后，利用压差作用下进入的少量空气缓慢氧化还原后物质，以制备符合预期要求的Fe－Fe3O4核壳结构纳米粒子，并分析产物的X射线衍射（X-ray diffraction，XRD）、透射电子显微镜（transmission electron microscopy，TEM）和振动样品磁强计（vibrating sample magnetometer，VSM）表征结果。结果通过还原-氧化法制备的Fe-Fe3O4核壳结构纳米粒子，形状近似球形，粒径主要分布在60-100nm，比饱和磁化强度达108emu／g，比Fe3O4纳米颗粒高30emu／g，且稳定性良好。结论还原-氧化法制备的Fe-Fe3O4核壳结构纳米颗粒比前躯体磁性强，并具有较高的化学稳定性和生物相容性。

Synthesis and characterization of Fe-Fe3O4 core-shell nanoparticles

Objective Through the procedure of reduction and oxidation, Fe3O4 nanoparticles, as the precursor,were changed into Fe/Fe3O4 core-shell nanoparticles to produce magnetic materials for targeting drug carrier. Methods Fe3O4 nanoparticles were first reduced by H2 in a tube furnace and then the remaining materials were slowly oxidized in a thin air atmosphere caused by the pressure difference inside and outside the tube furnace. The products were analyzed by X-ray diffraction （XRD）, transmission electron microscopy （TEM） and vibrating sample magnetometer （VSM） Results The as-synthesized particles were almost spherical, the particle diameter ranged from 60nm to 100 nm. The special saturation magnetization was 108emu/ g,30emu/g higher than the precursor. Conclusions The Fe/Fe3O4 core-shell structure shows higher special saturation magnetization than the precursor as well as greater chemical stability and biocompatibility.