| 半水合雌二醇贴剂治疗绝经期症状的临床观察 |
| |
| 引用本文： | 郁琦,郭欣,张以文. 半水合雌二醇贴剂治疗绝经期症状的临床观察[J]. 实用妇产科杂志, 2010, 26(2) |
| |
| 作者姓名： | 郁琦 郭欣 张以文 |
| |
| 作者单位： | 1. 中国医学科学院,北京协和医学院,北京协和医院,北京,100730
2. 北京市东城区妇幼保健院,北京,100007 |
| |
| 摘 要： | 目的:评价半水合雌二醇贴荆(松奇)治疗绝经期症状的安全性、有效性和药物不良反应.方法:60例绝经期妇女,血清FSH>30 U/L,E_2<109.8 pmol/L,随机分为实验组和对照组.实验组30例,连续使用半水合雌二醇贴剂,每7日更换1次,并每日口服甲羟孕酮2 mg;对照组30例,每日口服戊酸雌二醇1.5 mg,甲羟孕酮2 mg;两组连续治疗12周.用药前及用药12周观察绝经症候群,测血清E_2、FSH、脂蛋白、凝血功能,并观察安全性指标及药物不良反应.结果:两组绝经相关症状评分Kupperman指数有明显降低,绝经症候群有极显著改善,两组E_2均值有明显升高.肝、肾功能,凝血功能及血糖无明显变化;实验组用药后脂蛋白a[Lp(a)]值明显下降,血脂谱其余各项均无明显变化.两组其他安全性指标差异无统计学意义.结论:半水合雌二醇贴剂治疗绝经期症状是安全、有效的,尤其适用于不适宜选择口服途径用药的妇女.
|
| 关 键 词： | 绝经症候群 雌激素 激素治疗 |
Clinical Observation of E_2 Transdermal Patch in the Treatment of Menopausal Syndrome |
| |
| YU Qi,GUO Xin,ZHANG Yiwen. Clinical Observation of E_2 Transdermal Patch in the Treatment of Menopausal Syndrome[J]. Journal of Practical Obstetrics and Gynecology, 2010, 26(2) |
| |
| Authors: | YU Qi GUO Xin ZHANG Yiwen |
| |
| Affiliation: | YU Qi1,GUO Xin2,ZHANG Yiwen1(1.Peking Union Medical College Hospital,Chinese Academy of Medical Sciences , Peking Union Medical College,Beijing 100730,China,2.Maternal , Child Health Hospital of Dongcheng District,Beijing 100007,China) |
| |
| Abstract: | Objective:To evaluate the security,efficacy and side effects of E2 transdermal patch(Fem-7)in the treatment of menopausal syndrome.Methods:A total of 60 cases with menopausal syndrome(bloodserum FSH>30 U/L,E2<109.8 pmol/L)were randomly divided into treatment group(Fem-7 group)and control group(estrodiol valerate(E2V)group)for 12 weeks treatment.Fem-7 group changed patch every 7 days and took the 2 mg medroxyprogesterone(MPA)every day.While the E2V group took the 2 mg MPA and 1.5 mg E2V every day.Serum E2,FS... |
| |
| Keywords: | Symptom of menopause Estrogen Hormone threapy |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
