雷贝拉唑三联疗法治疗幽门螺杆菌相关性消化性溃疡的疗效观察

目的观察雷贝拉唑三联疗法治疗幽门螺杆菌(Hp)相关性消化性溃疡的临床疗效。方法将胃镜检查经快速尿素检测和病理检查为Hp阳性或14C呼气试验检测阳性患者60例随机分为雷贝拉唑组35例和奥美拉唑组25例。雷贝拉唑组每天口服雷贝拉唑10mg、克拉霉素500mg、甲硝唑400mg,均每天2次,疗程5d;奥美拉唑组每天口服奥美拉唑20mg、克拉霉素500mg、甲硝唑400mg,均每天2次,疗程7d。比较2组治疗总有效率、Hp根除率及溃疡愈合率。结果 2组总有效率及Hp根除率比较差异均无统计学意义(P>0.05)。雷贝拉唑溃疡愈合率为91.4%高于奥美拉唑组的64.0%,差异有统计学意义(P<0.01)。结论雷贝拉唑三联疗法能明显缓解消化性溃疡症状,对溃疡有较高的愈合率及Hp清除率。

The effect observation of rabeprazole triple therapy in helicobacter pylori-associated peptic ulcer

Objective To observe the effect of rabeprazole triple therapy in helicobacter pylori（Hp） -associated peptic ulcer.Methods 60 cases patients with Hp-associated peptic ulcer were randomly divided into rabeprazole group（35 cases） and omeprazole group（25 cases） .Rabeprazole group were given rabeprazole 10mg,clarithromycin 500mg,metronidazole 400mg,all twice a day;Omeprazole group were given omeprazole 20mg,clarithromycin 500mg,metronidazole 400mg,all twice a day.Compared the total effective,Hp eradication rate and ulcer healing rates of two groups.Results The total effective rate and Hp eradication rate of two groups were no significant difference（P0.05） .Ulcer healing rate of rabeprazole group（91.4%） was higher than that of omeprazole group（64.0%） ,the difference was statistically significant（P0.01） .Conclusion Rabeprazole triple therapy can relieve the symptom of peptic ulcer,the ulcer healing rate and Hp clearance rate is high.