| 甘草与附子配伍对乌头碱、新乌头碱、次乌头碱大鼠药动学的影响 |
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| 引用本文： | Shen H,Zhu LY,Yao N,Wu J. 甘草与附子配伍对乌头碱、新乌头碱、次乌头碱大鼠药动学的影响[J]. 中药材, 2011, 34(6): 937-942 |
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| 作者姓名： | Shen H Zhu LY Yao N Wu J |
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| 作者单位： | 江苏省中医药研究院江苏省现代中药制剂工程研究技术中心; |
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| 基金项目： | 江苏省中医药管理局课题(LB09056) |
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| 摘 要： | 目的:建立HPLC-MS同时测定大鼠血浆中的乌头碱、新乌头碱、次乌头碱含量的方法,并用于研究大鼠口服3种含附子煎液后乌头碱、新乌头碱、次乌头碱的药动学变化。方法:3组大鼠分别灌胃附子煎液(A液)、甘草附子单煎合并液(B液)、甘草附子合煎液(C液),附子剂量均为1.5 g/kg,HPLC-MS法测定乌头碱、新乌头碱、次乌头碱的血药浓度,用DAS 2.0数理统计软件分别计算其药动学参数。结果:甘草与附子配伍后,三种乌头碱的Cmax、AUC均降低,MRT、t1/2均延长,Tmax无明显变化。甘草附子合煎液相比于甘草附子单煎合并液,Cmax、AUC更低,MRT、t1/2更长。结论:甘草能够显著影响附子中三种乌头碱的药动学。
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| 关 键 词： | 乌头碱 新乌头碱 次乌头碱 HPLC-MS法 药动学 附子 甘草附子配伍 |
The effect of the compatibility of Radix Aconiti Laterlis and radix glycyrrhizae on pharmacokinatic of aconitine, mesaconitine and hypacmitine in rat plasma |
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| Shen Hong,Zhu Ling-ying,Yao Nan,Wu Jie. The effect of the compatibility of Radix Aconiti Laterlis and radix glycyrrhizae on pharmacokinatic of aconitine, mesaconitine and hypacmitine in rat plasma[J]. Journal of Chinese medicinal materials, 2011, 34(6): 937-942 |
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| Authors: | Shen Hong Zhu Ling-ying Yao Nan Wu Jie |
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| Affiliation: | SHEN Hong,ZHU Ling-ying,YAO Nan,WU Jie(Jiangsu Provincial Insititute of Traditional Chinese Medicine,Jiangsu Research Center for Modern TCM Pharmaceutics Process,Nanjing 210028,China) |
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| Abstract: | Objective:To established an HPLC-MS assay to determine aconitine,mesaconitine and hypaconitine simultaneously in rat plasma and be used to investigate the pharmacokinetics of the three alkaloids.Methods:Three groups of rats were orally administered respectively with three decoctions including decoction of Radix Aconiti Laterlis,blend decoction of Radix Aconiti Laterlis and Radix Glycyrrhizae which decocted separately,decoction of Radix Aconiti Laterlis and Radix Glycyrrhizae which decocted together,the dosa... |
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| Keywords: | Aconitine Mesaconitine Hypaconitine HPLC-MS Pharmacokinetics the Compatibility of Radix Aconiti Laterlis and Radix Glycyrrhizae |
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