放疗对广泛期小细胞肺癌预后影响的多因素分析

目的探讨影响广泛期小细胞肺癌（SCLC）放疗后预后的各种相关因素。方法回顾性分析63例广泛期SCLC放疗后患者的临床资料并随访，采用Cox模型行多因素分析。结果63例患者的1年生存率为39．89％，2年生存率11．81％，中位生存期为10．77个月。单因素分析显示患者KPS评分、是否脑转移、有无接受胸部放疗、接受化疗周期数对患者的生存期有影响。多因素分析显示接受化疗周期数、有无接受胸部放疗、KIPS评分是预测预后的独立因素。结论未发生脑转移、化疗周期数≥4、接受过胸部放疗、KPS评分≥80分均提示广泛期SCLC患者的预后较好。

Multivariate analysis of prognostic factors in 63 patients with extensive stage small cell lung cancer after radiotherapy

Objective To evaluate the prognostic factors in patients with extensive stage small cell lung cancer （SCLC） after radiotherapy. Methods Retrospective study was conducted including a total of 63 patients with extensive stage SCLC after radiotherapy. The edian survival time and overall survival rate were observed. Results The overall 1 and 2 year survival rates were 39.89% and 11.81% ,respectively . The edian survival time was 10.77months. Single factor analysis showed that patients KPS score,whether with brain metastasis,whether or not to accept the chest radiotherapy, and chemotherapy cycle numbers had influence on patients survival. Many factors analysis showed that chemotherapy cycle count, whether to accept the chest radiotherapy,and KPS score were independent prognostic factors. Conclusion No brain metastasis,chemotherapy cycle numbers ≥ 4, received chest radiotherapy,and KPS quartile score ≥ 80 points suggested that the prognosis of patients with extensive SCLC is good.