Pro-inflammatory activity in rats of thiocyanate, a metabolite of the hydrocyanic acid inhaled from tobacco smoke |
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Authors: | Michael Wellesley Whitehouse Mark Jones |
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Affiliation: | (1) Department of Pathology, University of Adelaide, Adelaide, SA, 5005, Australia;(2) Therapeutics Research Unit, Department of Medicine, University of Queensland, Brisbane, QLD, Australia;(3) School of Biomolecular and Physical Sciences, Griffith University, Nathan, QLD, 4111, Australia;(4) Queensland Clinical Trials Centre, School of Population Health, University of Queensland, Princess Alexandra Hospital, Woolloongabba, QLD, 4102, Australia;(5) PO Box 68, Stones Corner, QLD, 4120, Australia |
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Abstract: | Objective To seek a mechanism linking tobacco smoking with the increased incidence and severity of rheumatoid arthritis, deduced from many retrospective surveys, by studying arthritis/fibrosis development in rats. |
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