阿奇霉素联合布地奈德混悬液雾化吸入治疗小儿支原体肺炎的临床效果

目的探讨阿奇霉素联合布地奈德混悬液雾化吸入治疗小儿支原体肺炎的临床效果。方法将2015年10月至2019年1月我院收治的300例小儿支原体肺炎患儿按照随机数表法分为对照组与观察组,各150例。对照组采用阿奇霉素序贯疗法,观察组在对照组基础上给予布地奈德混悬液雾化吸入治疗。比较两组患儿治疗前、后的肺功能情况、血清IgE、外周血嗜酸性粒细胞(EOS)、炎症因子水平及临床疗效。结果治疗后,两组的FVC%、FEV1%、PEF%、MEF25%、MEF50%均有所提高,且观察组显著高于对照组(P<0.05)。治疗后,两组的IgE及EOS水平均有所下降,且观察组显著低于对照组(P<0.05)。治疗后,两组的IL-4水平均下降,IL-12、IFN-γ水平均升高,且观察组优于对照组(P<0.05)。观察组的治疗总有效率为91.33%,显著高于对照组的80.67%(P<0.05)。结论阿奇霉素联合布地奈德混悬液雾化吸入在小儿支原体肺炎的治疗中具有良好的效果,可降低炎症因子水平,有效改善患儿的肺功能,值得临床推广。

Clinical effect of azithromycin combined with aerosol inhalation of budesonide suspension in the treatment of mycoplasma pneumonia in children

Objective To investigate the clinical effect of azithromycin combined with aerosol inhalation of budesonide suspension in the treatment of mycoplasma pneumonia in children. Methods A total of 300 children with mycoplasma pneumonia admitted in our hospital from October 2015 to January 2019 were divided into control group and observation group according to random number table method, with 150 cases in each group. The control group was treated with azithromycin sequential therapy, and the observation group was treated with aerosol inhalation of budesonide suspension on the basis of the control group. Lung function, the levels of serum IgE, peripheral blood eosinophil(EOS), inflammatory factor before and after treatment and clinical efficacy were compared between the two groups. Results After treatment,FVC%, FEV1%, PEF%, MEF25%, MEF50% of the two groups increased, and those in the observation group were significantly higher than the control group(P<0.05). After treatment, the levels of IgE and EOS in both groups decreased,and those in the observation group were lower than the control group(P<0.05). After treatment, the level of IL-4 decreased in both groups, the levels of IL-12 and IFN-γ increased, and those in the observation group were better than the control group(P<0.05). The total effective rate of treatment in the observation group was 91.33%, which was significantly higher than 80.67% in the control group(P <0.05). Conclusion Azithromycin combined with aerosol inhalation of budesonide suspension in the treatment of mycoplasma pneumonia in children has a good effect, it can reduce the level of inflammatory factors, effectively improve the lung function of children, which is worthy of clinical promotion.