还少丹联合多奈哌齐对血管性痴呆患者血清GSH-Px、MDA水平的影响

目的评估还少丹联合多奈哌齐治疗对血管性痴呆患者血清谷胱甘肽过氧化物酶(GSHPx)、丙二醛(MDA)水平的影响。方法125例轻中度血管性痴呆患者作为研究对象,随机分为A组(65例)和B组(60例)。A组患者给予还少丹联合多奈哌齐治疗,B组患者给予多奈哌齐治疗。比较两组患者治疗前及治疗第12周的简易智力状态检查量表(MMSE)评分、日常生活活动能力(ADL)评分、GSH-Px、MDA水平及不良反应发生情况。结果治疗第12周,A组患者的MMSE、ADL评分高于本组治疗前和B组治疗第12周,差异均具有统计学意义(P<0.05);B组治疗前及治疗第12周MMSE、ADL评分比较,差异无统计学意义(P>0.05)。治疗第12周,A组的GSH-Px水平高于本组治疗前及B组治疗第12周,MDA水平低于治疗前及B组治疗第12周,差异均具有统计学意义(P<0.05);但B组治疗前与治疗第12周的GSH-Px、MDA水平比较差异无统计学意义(P>0.05)。A组的不良反应发生率4.62%低于B组的15.0%,差异具有统计学意义(P<0.05)。结论还少丹与多奈哌齐联合应用能更快改善轻中度血管性痴呆患者认知功能,还能通过增加GSH-Px活性,降低MDA含量来抑制神经细胞凋亡,促进脑功能恢复。

Effect of Huanshao mini-pills combined with donepezil on serum GSH-Px and MDA levels in patients with vascular dementia

Objective To evaluate the effect of Huanshao mini-pills combined with donepezil on serum glutathione peroxidase(GSH-Px)and malondialdehyde(MDA)levels in patients with vascular dementia.Methods A total of 125 cases of mild to moderate vascular dementia as study subjects were randomly divided into group A(65 cases)and group B(60 cases).Group A was treated with Huanshao mini-pills combined with donepezil,group B was treated by donepezil.The mini-mental state examination(MMSE)score and activities of daily life(ADL)score before treatment and after 12 weeks of treatment,GSH-Px and MDA level,and occurrence of adverse reactions were compared between the two groups.Results After 12 weeks of treatment,the MMSE and ADL score in group A was higher than those before treatment and that in group B after 12 weeks of treatment.Their difference was statistically significant(P<0.05).Before treatment and after 12 weeks of treatment,there was no statistically significant difference in MMSE and ADL score in group B(P>0.05).After 12 weeks of treatment,the GSHPx level in group A was higher than that before treatment and that in group B after 12 weeks of treatment,and MDA level was lower than that before treatment and that in group B after 12 weeks of treatment.Their difference was statistically significant(P<0.05).Before treatment and after 12 weeks of treatment,there was no statistically significant difference in GSH-Px and MDA level in group B(P>0.05).The incidence of adverse reactions 4.62%in group A was lower than 15.0%in group B,and the difference was statistically significant(P<0.05).Conclusion The combination of Huanshao mini-pills and donepezil can improve the cognitive function of patients with mild to moderate vascular dementia more quickly.It can also inhibit neuronal apoptosis and promote the recovery of brain function by increasing GSH PX activity and reducing MDA content.