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| 小分子化合物在干细胞诱导分化为视网膜色素上皮细胞中的应用 | |
| 引用本文： | 高珍,彭广华. 小分子化合物在干细胞诱导分化为视网膜色素上皮细胞中的应用[J]. 眼科新进展, 2016, 0(7): 688-691. DOI: 10.13389/j.cnki.rao.2016.0183 |
| 作者姓名： | 高珍 彭广华 |
| 作者单位： | 450052 河南省郑州市，郑州大学第一附属医院眼科 |
| 基金项目： | 国家重点基础研究发展计划(2013CB967001)，国家自然科学基金项目(编号:31271400、31470065)National Key Basic Research Program of China(2013CB967001)，National Natural Science Foundation of China(31271400 |
| 摘 要： | 视网膜色素上皮细胞的变性、坏死将导致患者的视力丧失。由于视网膜色素上皮细胞不能再生，移植健康的视网膜色素上皮细胞已成为视网膜变性性疾病最具有前景的治疗策略。随着化学、分子生物学和再生医学的发展，人们发现越来越多的小分子化合物通过调控某些特定的信号通路，能够操纵干细胞的分化方向。本文主要对小分子化合物在体外诱导干细胞定向分化为视网膜色素上皮细胞的应用作一综述。 |
| 关 键 词： | 小分子化合物 干细胞 视网膜色素上皮细胞 |
Application of small molecule compounds in inducing differentiation of stem cells into retinal pigment epithelial cells |
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| GAO Zhen,PENG Guang-Hua. Application of small molecule compounds in inducing differentiation of stem cells into retinal pigment epithelial cells[J]. Recent Advances in Ophthalmology, 2016, 0(7): 688-691. DOI: 10.13389/j.cnki.rao.2016.0183 | |
| Authors: | GAO Zhen PENG Guang-Hua |
| Affiliation: | Department of Ophthalmology, the First Affiliated Hospital of Zhengzhou University , Zhengzhou 450052 , Henan Province , China |
| Abstract: | The degeneration and necrosis of retinal pigment epithelial( RPE) cells is the leading cause of vision loss in patients. Because the RPE cells cannot regenerate, healthy RPE cells transplantation has become the most promising strategies for the treatment of retinal degeneration diseases. With the development of chemistry,molecular biology and regenerative medicine .more and more small molecule compounds which manipulate stem cells differentiation by regulating the certain signaling pathways are discovered. This review reviews the applications of small molecule compounds in regulateing differentiation of stem cells into RPE cells in vitro. |
| Keywords: | small molecule compounds stem cells retinal pigment epithelial cells |
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