Vogt-小柳-原田综合征黄斑中心凹脉络膜厚度分析

目的　分析Ｖｏｇｔ-小柳-原田综合征患者急性期与恢复期黄斑中心凹下方脉络膜厚度（ｓｕｂｆｏｖｅａｌｃｈｏｒｏｉｄａｌｔｈｉｃｋｎｅｓｓ，ＳＦＣＴ）变化。方法　３０例Ｖｏｇｔ-小柳-原田综合征患者６０眼纳入研究，其中男１４例，女１６例，年龄（４５．３８±１０．１９）岁。所有患者均行眼前节检查、最佳矫正视力、眼底彩色照相、眼底血管荧光造影（ｆｕｎｄｕｓｆｌｕｏｒｅｓｃｅｉｎａｎｇｉｏｇｒａｐｈｙ，ＦＦＡ）及频域光学相干断层扫描（ｓｐｅｃｔｒａｌｄｏｍａｉｎｏｐｔｉｃａｌｃｏｈｅｒｅｎｃｅｔｏｍｏｇｒａｐｈｙ，ＳＤ-ＯＣＴ）等检查确诊。经糖皮质激素口服治疗前及治疗２周、６个月、１２个月后应用ＳＤ-ＯＣＴ对Ｖｏｇｔ-小柳-原田综合征患者进行深度加强扫描（ｅｎｈａｎｃｅｄｄｅｐｔｈｉｍａｇｉｎｇ，ＥＤＩ）测量ＳＦＣＴ。与正常同龄人群ＳＦＣＴ值进行比较。结果　患眼与正常同龄人群ＳＦＣＴ值（２８７．８５±２７．７０）μｍ比较，糖皮质激素治疗前，患眼ＳＦＣＴ厚度（４３７．４６±３０．１４）μｍ明显增加，差异有统计学意义（ｔ＝３．５９１，Ｐ＜０．０１）。治疗２周后，患眼ＳＦＣＴ厚度为（３５２．５０±６０．３７）μｍ，较治疗前显著下降，差异有统计学意义（ｔ＝２．５６７，Ｐ＜０．０５）。治疗６个月及１２个月后，患眼ＳＦＣＴ厚度分别为（２９９．３２±２０．１２）μｍ、（２９７．６１±２１．８９）μｍ，与正常人群ＳＦＣＴ值比较，差异均无统计学意义（ｔ＝１．３６２、１．２７２，均为Ｐ＞０．０５）。结论　Ｖｏｇｔ-小柳-原田综合征患者急性期ＳＦＣＴ较正常同龄人群明显增厚，恢复期与同龄正常人群比较无明显差别。

Subfoveal choroidal thickness in eyes with Vogt-Koyanagi-Harada disease

Objective To research the subfoveal choroidal thickness ( SFCT) in the acute and successive stages of Vogt-Koyanagi-Harada disease. Methods Thirty patients ( 60 eyes) with VKH were enrolled in this study. The patients included 14 males and 16 females,with a mean age of (45. 38 + 10. 19) years old. A1l the patients that had been exanuned slit-lamp check,best corrected visual acuity ( BCVA) ,fundus color photography,fundus fluorescein angiography ( FFA) and spectral domain optical coherence tomography ( SD-OCT) were recuited. Glucocorticoid was administered to all patients. The SFCT were measured by SD-OCT with enhanced depth imaging ( EDI) on all the patients before the treatment and 2 weeks ,6 months and 12 months after treatment . and was compared with the average SFCT in normal eyes. Results Before treatment , SFCT of affected eyes was (437. 46 +30. 14) Vm,which was significantly thicker than normal SFCT ( 287. 85 + 27. 70) Vm( t = 3. 591 ,P < 0. 01 ) . Two weeks after treatment . SFCT of affected eyes was( 352. 50 +60. 37) ym , and was significantly thinner than that before treatment ( t = 2. 567 .P < 0. 05) . SFCT of affected eyes at 6 months and 12 months after treatment were (299. 32 + 20. 12) Vm ( 297. 61 + 21. 89) Vm, respectively , there was no significant difference compared with normal eyes ( t = 1. 362 . 1. 272 ; all P > 0. 05 ) . Conclusion SFCT in the acute stages of VKH patients is significantly thicker than that in normal subjects , and no difference in successive stages of VKH patients.