Unstable vancomycin heteroresistance is common among clinical isolates of methiciliin-resistant Staphylococcus aureus |
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| Authors: | Plipat Nottasorn Livni Gilat Bertram Heidi Thomson Richard B |
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| Affiliation: | Division of Pediatric Infectious Diseases, Department of Pediatrics, Siriraj Hospital, Mahidol University, 2 Prannok Road, Bangkoknoi, Bangkok 10700, Thailand. nplipat@msn.com |
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| Abstract: | We tested 109 unique, vancomycin-susceptible, methicillin-resistant Staphylococcus aureus (MRSA) strains for vancomycin heteroresistance by a selection method, i.e., step-wise exposure of large inoculums to increasing concentrations of vancomycin. Although no strains demonstrated stable heteroresistance, 81 strains (74%) demonstrated unstable heteroresistance. Unstable heteroresistance is common among clinical isolates of MRSA and may represent a cause of therapeutic failure. |
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