Therapeutic and immune effects of 5‐aminolevulinic acid photodynamic therapy on UVB‐induced squamous cell carcinomas in hairless mice |
| |
| Authors: | Ting Lv Qingfeng Tu Zheng Huang Xiuli Wang |
| |
| Institution: | 1. Department of Dermatology and Venereology, Shanghai Skin Diseases Hospital, , Shanghai, China;2. CAPT Lab and Cancer Center, University of Colorado Denver, , Denver, CO, USA;3. MOE Key Laboratory of OptoElectronic Science and Technology for Medicine, Fujian Provincial Key Laboratory for Photonics Technology, Fujian Normal University, , Fuzhou, China |
| |
| Abstract: | The therapeutic effects of 5‐aminolevulinic acid (ALA)‐mediated photodynamic therapy (PDT) on cutaneous squamous cell carcinoma (SCC) are not fully understood, and the usefulness of topical PDT in the treatment of SCC is still debatable. The most interesting aspect in SCC PDT is perhaps its potential in inducing antitumor immune responses. In this study, cutaneous SCCs were established by UVB irradiation of hairless mice and treated with multiple ALA PDT. Immunohistochemistry assays showed that ALA PDT could induce quick apoptosis, overexpression of TNFα and marked increases in DCs, CD4+ and CD8+ cells in tumor interstitium and subcutaneous connective tissues. However, a complete response was only achieved for small SCCs. The clinical value of ALA PDT‐induced specific antitumor immune responses in long‐term control of SCCs deserves further study. |
| |
| Keywords: |
5‐aminolevulinic acid
hairless mouse immune responses squamous cell carcinoma topical photodynamic therapy
UVB
|
|
|
