Reactivity of the 1,3‐β‐D‐glucan assay during bacteraemia: limited evidence from a prospective study |
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Authors: | Zdenek Racil Iva Kocmanova Martina Toskova Jana Winterova Martina Lengerova Shira Timilsina Jiri Mayer |
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Affiliation: | 1. Department of Internal Medicine, Hematology and Oncology, Masaryk University and University Hospital Brno, Brno, Czech Republic;2. CEITEC – Central European Institute of Technology, Masaryk University Brno, Brno, Czech Republic;3. Department of Microbiology, University Hospital Brno, Brno, Czech Republic |
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Abstract: | There are discrepancies in the retrospective studies published in literature of whether or not bacteraemia could lead to false positivity of 1,3‐β‐D (BG) glucan assay. We performed, for the first time, a prospective study evaluating the role of bacterial bloodstream infection to the reactivity of BG assay. Twenty‐six episodes of bacteraemia that occurred in high‐risk haematological patients were included in our study. Consecutive BG levels >80 pg ml?1 were required for test positivity. Only 2 of 26 patients were BG positive – both with IFDs. Thus, we prospectively did not prove bacteraemia as the source of cross reactivity of BG assay in haematological patients. |
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Keywords: | 1,3‐β ‐D‐glucan bacteraemia haematological malignancy |
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