放射加热疗治疗局部晚期非小细胞肺癌的研究

［目的］评价放射加热疗治疗局部晚期非小细胞肺癌（NSCLC）的疗效。（方法）采用随机配对的方法将不能手术的ⅢaⅢb。期NSCLC患者分为两组，A组采用放疗加热疗，B组单纯放疗。（结果〕A组和B组肿瘤有效率（C＋PR）分别为91．18％、82.35％（P=0.05）；A组急性放射反应和后期放射损伤较B组明显减轻（P值分别为0．03和0．035）；3年生存率分别为11．76％和8.82％（P＝00158），3年局控率为7.84％和5.88％（P=0．0398），3年无远处转移率分别为19．16％和18．42％（P=0.0213）。（结论）放疗加热疗治疗局部晚期NSCDLC疗效优于单纯放射治疗，且可减轻急性放射反应和后期放射损伤。

Hyperthermia Combined with Radiotherapy in the Treatment of Regional Advanced non Small Cell Lung Cancers

To evaluate the rmCaCy of the hperthenda cedined with ndothmp in the bot of nded edvanced im edcell lung canan(NSde). [ Methods]The Patients with ortable NSCix of mp m.' mb were whdrind into two gnpe: Gmp A: Thehyperthenda edined with edothempy op. Gmp B: The ndotheraPy alone gup. L ResultsJThe resmpes rate(CR PR), 3-yun survivaltale disease be Iate and distant bos be the were 9l. l8%,82.35%(P = o.o5), ll .76%,8.82% (P = o.ol58),7.84%,5 .88% (P= o.o398)and l9. l6%, l8.42% (P = o.o2l3)in ~ A and ~ B ~vely.The arute tokicities and the late damag of taliothemp inthe grDUp A were less severe than that in the group B. [Conclusion]These data show that hyperthermia combined with ndotheIaPy is favorable int-t for ndonal advanced NSCre.